Academic Journal
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans
| العنوان: | Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans |
|---|---|
| المؤلفون: | Gómez‐Escribano, Ana P, Mora‐Martínez, Carlos, Roca, Marta, Walker, Denise S, Panadero, Joaquín, Sequedo, Maria D, Saini, Ratni, Knölker, Hans‐Joachim, Blanca, Jose, Burguera, Juan, Lahoz, Agustin, Cañizares, Joaquin, Millán, José M, Burton, Nick O, Schafer, William R, Vázquez‐Manrique, Rafael P |
| المساهمون: | Federal Railroad Administration |
| المصدر: | EMBO reports ; volume 24, issue 6 ; ISSN 1469-221X 1469-3178 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Alzheimer's, Parkinson's and Huntington's diseases can be caused by mutations that enhance protein aggregation, but we still do not know enough about the molecular players of these pathways to develop treatments for these devastating diseases. Here, we screen for mutations that might enhance aggregation in Caenorhabditis elegans , to investigate the mechanisms that protect against dysregulated homeostasis. We report that the stomatin homologue UNC‐1 activates neurohormonal signalling from the sulfotransferase SSU‐1 in ASJ sensory/endocrine neurons. A putative hormone, produced in ASJ, targets the nuclear receptor NHR‐1, which acts cell autonomously in the muscles to modulate polyglutamine repeat (polyQ) aggregation. A second nuclear receptor, DAF‐12, functions oppositely to NHR‐1 to maintain protein homeostasis. Transcriptomics analyses of unc‐1 mutants revealed changes in the expression of genes involved in fat metabolism, suggesting that fat metabolism changes, controlled by neurohormonal signalling, contribute to protein homeostasis. Furthermore, the enzymes involved in the identified signalling pathway are potential targets for treating neurodegenerative diseases caused by disrupted protein homeostasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.15252/embr.202255556 |
| الاتاحة: | http://dx.doi.org/10.15252/embr.202255556 https://www.embopress.org/doi/pdf/10.15252/embr.202255556 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.F032248C |
| قاعدة البيانات: | BASE |
| DOI: | 10.15252/embr.202255556 |
|---|