Academic Journal
S1 Checklist -
| العنوان: | S1 Checklist - |
|---|---|
| المؤلفون: | Chethan Purushothama, Byron Lawrence Crape, Valentina Stolyarov, Altynshash Jaxybayeva, Philip la Fleur, Jeby Jose Olickal |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Biotechnology, Sociology, Cancer, Mental Health, Infectious Diseases, secondary outcome measures, primary outcome measure, control tobacco use, term quit rates, help smokers quit, acting nrt alone, study may help, study may gather, preloaded combination nrt, combination nrt resulting, blind superiority trial, combination nrt, control group, nrt ), study aims, |
| الوصف: | Background Tobacco use is a major cause of premature death and disease in Kazakhstan, with over 22,500 deaths per year. Although efforts have been made to control tobacco use, smoking-related deaths have continued to increase. One strategy to help smokers quit is to use nicotine replacement therapy (NRT), with combination NRT resulting in higher long-term quit rates than a single form of NRT. A study aims to determine the effectiveness of preloaded combination NRT on smoking cessation, the change in health-related quality of life due to smoking cessation, and explore treatment adherence perceptions. Methods and analysis The study will be conducted as a randomized, single-blind superiority trial, with 100 participants in each arm. The trial will be carried out at the National Research Cardiac Surgery Center, Astana, Kazakhstan, and will recruit current smokers aged 18 years and above with a motivation to quit. Participants will be randomly allocated to either the intervention group or the control group. The former will receive preloaded combination NRT, while the latter will receive fast-acting NRT alone. The primary outcome measure will be sustained abstinence from smoking after six months. Secondary outcome measures will include health-related quality of life and adherence to the treatment. Discussion The study may gather further evidence that a combination NRT is more efficient than a fast-acting NRT alone. The findings of this study may help to improve tobacco cessation strategies in Kazakhstan and other countries with high smoking prevalence rates. Trial registration number NCT05484505 . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/S1_Checklist_-/24641351 |
| DOI: | 10.1371/journal.pone.0292490.s001 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0292490.s001 https://figshare.com/articles/journal_contribution/S1_Checklist_-/24641351 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.EFD9DDC6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0292490.s001 |
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