Academic Journal
Circular RNAs as Key Regulators in Cancer Hallmarks: New Progress and Therapeutic Opportunities.
| العنوان: | Circular RNAs as Key Regulators in Cancer Hallmarks: New Progress and Therapeutic Opportunities. |
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| المؤلفون: | Hussen, Bashdar Mahmud, Abdullah, Snur Rasool, Jaafar, Rayan Mazin, Rasul, Mohammed Fatih, Aroutiounian, Rouben, Harutyunyan, Tigran, Liehr, Thomas, Samsami, Majid, Taheri, Mohammad |
| المصدر: | Crit Rev Oncol Hematol ; ISSN:1879-0461 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2025 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Biomarker, CircRNA, Drug Resistance, Hallmarks of Cancer, Tumor Therapy |
| الوصف: | Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various cancer hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, and tissue-specific expression. These non-coding RNAs function through mechanisms such as miRNA sponging, interactions with RNA-binding proteins (RBPs), and modulating transcription and splicing. Advances in RNA sequencing and bioinformatics tools have enabled the identification and functional annotation of circRNAs across different cancer types. Clinically, circRNAs demonstrate high specificity and sensitivity in samples, offering potential as diagnostic and prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, and delivery systems are under investigation. However, their precise mechanisms remain unclear, and more clinical evidence is needed regarding their roles in cancer hallmarks. Understanding circRNAs will pave the way for novel diagnostic and therapeutic approaches, potentially improving patient outcomes. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| Relation: | https://doi.org/10.1016/j.critrevonc.2024.104612; https://pubmed.ncbi.nlm.nih.gov/39755160 |
| DOI: | 10.1016/j.critrevonc.2024.104612 |
| الاتاحة: | https://doi.org/10.1016/j.critrevonc.2024.104612 https://pubmed.ncbi.nlm.nih.gov/39755160 |
| Rights: | Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved. |
| رقم الانضمام: | edsbas.EFA5AD7F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.critrevonc.2024.104612 |
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