التفاصيل البيبلوغرافية
| العنوان: |
Global effects of itaconate and DI on transcriptomic responses in IAV-infected A549 cells. |
| المؤلفون: |
Aaqib Sohail (11944884), Azeem A. Iqbal (4991969), Nishika Sahini (668877), Fangfang Chen (302428), Mohamed Tantawy (11944887), Fakhar Waqas (11944890), Moritz Winterhoff (11944893), Thomas Ebensen (198767), Kristin Schultz (6078449), Robert Geffers (23730), Klaus Schughart (150782), Matthias Preusse (3548096), Mahmoud Shehata (9574695), Heike Bähre (519434), Marina C. Pils (7388180), Carlos A. Guzman (5650249), Ahmed Mostafa (354419), Stephan Pleschka (85578), Christine Falk (109913), Alessandro Michelucci (1806310), Frank Pessler (52000) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Microbiology, Cell Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Plant Biology, Virology, results reveal itaconates, human lung tissue, compounds differed greatly, cellular gene homeostasis, whereas akt phosphorylation, natural killer cells, >< sup ><, triggered interferon responses, compounds reversed infection, redirect inflammatory responses, murine macrophages independent, div >< p, >, reduced infection, exert antiviral effects, inflammatory chemokines cxcl10, infection induced expression, di reduced iav, inflammatory responses, stat1 phosphorylation, cxcl10 < |
| الوصف: |
A549 cells were infected with IAV (PR8M, MOI = 1) and gene expression was assessed by microarray analysis 24 h p.i. PCA based on the microarray analysis used for S11 – S13 Figs , but additionally including treatment with 0.25 mM DI. The PCA shows normalization of IAV-driven reprogramming of gene expression, but increasing impact of itaconate on cellular responses with increasing doses. Toxicity data and dose-response curves of the compounds for HA mRNA and CXCL10 mRNA expression are shown in S2 and S9 Figs , respectively. (TIF) |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Global_effects_of_itaconate_and_DI_on_transcriptomic_responses_in_IAV-infected_A549_cells_/18340200 |
| DOI: |
10.1371/journal.ppat.1010219.s010 |
| الاتاحة: |
https://doi.org/10.1371/journal.ppat.1010219.s010 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.EF6FCC21 |
| قاعدة البيانات: |
BASE |