Academic Journal
Stavudine-Induced Hyperlactatemia/Lactic Acidosis at a Tertiary Communicable Diseases Clinic in South Africa
| العنوان: | Stavudine-Induced Hyperlactatemia/Lactic Acidosis at a Tertiary Communicable Diseases Clinic in South Africa |
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| المؤلفون: | Hernández Pérez, Ernesto, Dawood, Halima |
| المصدر: | Journal of the International Association of Physicians in AIDS Care ; volume 9, issue 2, page 109-112 ; ISSN 1545-1097 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2010 |
| الوصف: | Objectives: To determine the incidence, presentation, and outcome of hyperlactatemia and lactic acidosis. Design and Methods Setting: Grey’s Hospital, a tertiary level referral institution. Study Population: A chart review of 1719 patients commenced on highly active antiretroviral therapy (HAART) between August 1, 2004, and July 31, 2006. A total of 1000 patients (615 females) received stavudine (d4T)/lamivudine (3TC)/efavirenz (EFV), 719 patients (598 females) received d4T/ 3TC/nevirapine (NVP). Results: Of the 1719 patients, 152 (8.84%) had an elevated plasma venous lactate (>2.2 mmol/L), 45 patients required admission for lactic acidosis. The overall incidence rate was 13.5 cases per 1000 patient years. The most common presenting symptoms were loss of weight (95%), abdominal pain (78.9%), loss of appetite, and paresthesias (63.8%). The median body mass index (BMI) at commencement of HAART and at onset of symptoms was 24.5 and 26, respectively. A median serum lactate level of 6.08 mmol/L (range 2.3-19.7 mmol/L) was observed at the onset of symptoms. Conclusions: High BMI at treatment initiation did not always predict hyperlactatemia. All patients who died had a baseline CD4 count <10 cells/mm 3 at HAART initiation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1545109710361536 |
| الاتاحة: | https://doi.org/10.1177/1545109710361536 https://journals.sagepub.com/doi/pdf/10.1177/1545109710361536 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.EF6A4DC4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1545109710361536 |
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