Academic Journal
Predictors of in-hospital mortality in HIV-infected patients with COVID-19
| العنوان: | Predictors of in-hospital mortality in HIV-infected patients with COVID-19 |
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| المؤلفون: | Moreno-Torres, Víctor, de Mendoza, Carmen, Martínez-Urbistondo, María, Mills, Patricia, Treviño, Ana, de la Fuente, Sara, Diaz de Santiago, Alberto, Calderon-Parra, Jorge, Pintos, Ilduara, Corpas, Manuel, Soriano, Vicente |
| بيانات النشر: | An International Journal of Medicine |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Internacional de La Rioja (UNIR): Re-Unir |
| مصطلحات موضوعية: | Coronavirus Disease 2019, HCV, genotype, JCR, Scopus |
| الوصف: | Background Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability. Design: Retrospective nationwide public database analysis. Methods Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list. Results A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19. Conclusion HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1460-2725 |
| Relation: | vol. 116, nº 1; https://academic.oup.com/qjmed/article/116/1/57/6680200; V Moreno-Torres, C de Mendoza, M Martínez-Urbistondo, P Mills, A Treviño, S de la Fuente, A Díaz de Santiago, J Calderón-Parra, I Pintos-Pascual, M Corpas, V Soriano, Predictors of in-hospital mortality in HIV-infected patients with COVID-19, QJM: An International Journal of Medicine, Volume 116, Issue 1, January 2023, Pages 57–62, https://doi.org/10.1093/qjmed/hcac215; https://reunir.unir.net/handle/123456789/14539; https://doi.org/10.1093/qjmed/hcac215 |
| DOI: | 10.1093/qjmed/hcac215 |
| الاتاحة: | https://reunir.unir.net/handle/123456789/14539 https://doi.org/10.1093/qjmed/hcac215 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.EF462E5D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14602725 |
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| DOI: | 10.1093/qjmed/hcac215 |