Academic Journal
Effects of irradiation on Plasmodium falciparum sporozoite hepatic development: implications for the design of pre‐erythrocytic malaria vaccines
| العنوان: | Effects of irradiation on Plasmodium falciparum sporozoite hepatic development: implications for the design of pre‐erythrocytic malaria vaccines |
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| المؤلفون: | Silvie, O., Semblat, J. P., Franetich, J. F., Hannoun, L., Eling, W., Mazier, D. |
| المصدر: | Parasite Immunology ; volume 24, issue 4, page 221-223 ; ISSN 0141-9838 1365-3024 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2002 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Immunization with irradiation‐attenuated Plasmodium sporozoites confer protection against live sporozoite challenge. Protection relies primarily on cytotoxic lymphocyte activity against infected hepatocytes, and is suppressed when sporozoites are over‐irradiated. Here, we demonstrate that over‐irradiated (25–30 krad) Plasmodium falciparum sporozoites invade human hepatocytes and transform into uninucleate liver‐trophozoites with the same efficiency as non‐irradiated and irradiation‐attenuated (12–15 krad) sporozoites. Since hepatocytes infected with over‐irradiated non‐protective sporozoites are likely to express sporozoite‐derived peptide/major histocompatibility complex class I molecules on their surface, our results strongly suggest that sporozoite proteins are not the main immunogens involved in protection, and thus may not per se constitute proper malaria vaccine candidates. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1365-3024.2002.00450.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1365-3024.2002.00450.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-3024.2002.00450.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-3024.2002.00450.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.EF451ED0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1365-3024.2002.00450.x |
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