Academic Journal
Paediatric nephrology II
| العنوان: | Paediatric nephrology II |
|---|---|
| المؤلفون: | Musial, Kinga, Zwolinska, Danuta, Pruthi, Rishi, Sinha, Manish, Casula, Anna, Lewis, Malcolm, Tse, Yincent, Maxwell, Heather, O'Brien, Catherine, Inward, Carol, Sharaf, Eman, Fadel, Fatina, Bazaraa, Hafez, Hegazy, Ranya, Essam, Rascha, Manickavasagar, Bahee, Shroff, Rukshana, McArdle, Andrew, Ledermann, Sarah, Shaw, Vanessa, Van't Hoff, William, Paudyal, Bandana, Prado, Gail, Schoeneman, Morris, Nepal, Manoj K., Feygina, Valeriya, Bansilal, Vaishali, Tawadrous, Hanan, Mongia, Anil K., Melk, A., Kracht, D., Doyon, A., Zeller, R., Litwin, M., Duzowa, A., Sözeri, B., Bayzit, A., Caliskan, S., Querfeld, U., Wühl, E., Schaefer, F., Schmidt, B., Canpolat, Nur, Caliskan, Salim, Kara Acar, Manolya, Pehlivan, Sukran, Tasdemir, Mehmet, Sever, Lale, Nüsken, Eva, Taylan, Christina, von Gersdorff, Gero, Schaller, Mathias, Barth, Claudia, Dötsch, Jörg, Roomizadeh, Peyman, Gheissari, Alaleh, Abedini, Amin, Garzotto, Francesco, Zanella, Monica, Kim, Jeong, Cena, Roberoto, Neri, Mauro, Nalesso, Federico, Brendolan, Alessandra, Ronco, Claudio, Celkan, Tiraje, Laçinel, Sibel, Keser, Ayse, Taner Elmas, Ahmet, Tabel, Yilmaz, Ipek, Sevcan, Karadag, Ahmet, Elmas, Ozlem, Ozyalin, Fatma, Hoxha (Qosja), Alketa, Gjyzari, Albana, Tushe, Eduard, Said, Ragia M., Abdel Fattah, Magid A., Soliman, Dina A., Mahmoud, Sahar Y., Hattori, Motoshi, Uemura, Osamu, Hataya, Hiroshi, Ito, Shuichi, Hisano, Masataka, Ohta, Toshiyuki, Fujinaga, Shuichiro, Kise, Tomoo, Goto, Yoshimitsu, Matsunaga, Akira, Hashimoto, Taeko, Tsutsumi, Yasushi, Ito, Naoko, Akizawa, Tadao, Maher, Sheren, Cho, Byoung-Soo, Choi, Yu-Mi, Suh, Jin-Soon, Farid, Farida, El-Hakim, Ihab, Salman, Mohamed, Rajnochova Bloudickova, Silvie, Viklicky, Ondrej, Seeman, Tomas, Yüksel, Selçuk, Çaglar, Murat, Becerir, Tülay, Tepeli, Emre, Çalli Demirkan, Nese, Yalçin, Nagihan, Ergin, Ahmet, Hladik, Michal, Sigutova, Radka, Vsiansky, Frantisek, Safarcik, Kristian, Svagera, Zdenek, Abd El Monem Soliman, Neveen, Bazaraa, Hafez Mohamed, Nabhan, Marwa Mohamed, Badr, Ahmed Mohamed, Abd El Latif Shahin, Mohamed, Skrzypczyk, Piotr, Panczyk-Tomaszewska, Malgorzata, Roszkowska-Blaim, Maria, Wawer, Zofia, Bienias, Beata, Zajaczkowska, Malgorzata, Szczepaniak, Marta, Pawlak-Bratkowska, Monika, Tkaczyk, Marcin, Kilis-Pstrusinska, Katarzyna, Jakubowska, Anna, Prikhodina, Larisa, Ryzhkova, Oxana, Poltavets, Natalia, Polyakov, Vladimir |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2013 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Abstracts |
| الوصف: | Introduction and Aims: Renal interstitial fibrosis is a final common pathway in chronic kidney disease (CKD) progression, independent of its origin. Matrix metalloproteinases (MMPs) are known for their proteolytic activity, regulating extracellular matrix content and tissue remodeling. The increased serum levels of MMPs have been described both in children and adults with different stages of CKD, showing their role in atherogenesis, apoptosis and inflammatory cell migration. However, the knowledge about MMP excretion with urine and its potential applicability as indicators of interstitial fibrosis in that group of patients is limited. There are no results of such investigation in children. There are either no data on the impact that EMMPRIN (extracellular matrix metalloproteinase inducer) could have on MMP urine excretion in CKD patients. The aim of the study was to assess the concentrations of MMP-2, MMP-7, MMP-9 and EMMPRIN both in serum and urine of predialysis CKD children and to analyze the potential relations between these parameters. The second goal was to search for correlations with markers of processes engaged in fibrosis, such as cell migration (sE-selectin) and apoptosis (sFas/sFasL), as well as CKD-related anomalies (inflammation, dyslipidemia). Methods: 41 children with predialysis CKD stages III-V were enrolled in the study. 23 age-matched subjects with primary nocturnal enuresis and normal kidney function served as controls. The concentrations of MMP-2, MMP-7, MMP-9, sE-selectin, sFas and sFasL were assessed by ELISA, hsCRP by nephelometry. Results: The median serum values of MMP-2, MMP-7, MMP-9, EMMPRIN, sE-selectin, sFas/sFasL were significantly elevated in CKD patients vs. controls. The urinary concentrations of all MMPs and EMMPRIN were markedly increased in CKD children when compared to the control group. The MMP-2 and MMP-9 levels in urine correlated significantly with the corresponding values in serum, whereas MMP-7 and EMMPRIN urine concentrations did not. All parameters examined in urine ... |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://ndt.oxfordjournals.org/cgi/content/short/28/suppl_1/i517; http://dx.doi.org/10.1093/ndt/gft157 |
| DOI: | 10.1093/ndt/gft157 |
| الاتاحة: | http://ndt.oxfordjournals.org/cgi/content/short/28/suppl_1/i517 https://doi.org/10.1093/ndt/gft157 |
| Rights: | Copyright (C) 2013, European Renal Association - European Dialysis and Transplant Association |
| رقم الانضمام: | edsbas.EF326738 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/gft157 |
|---|