Academic Journal
Can increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasia
| العنوان: | Can increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasia |
|---|---|
| المؤلفون: | Toprak, Kenan, Kaplangöray, Mustafa, Altıparmak, İbrahim Halil, Taşcanov, Mustafa Begenç, Güngören, Fatih, Fedai, Halil, İnanır, Mehmet, Biçer, Asuman, Demirbağ, Recep |
| المساهمون: | BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, orcid:0000-0003-1784-3584, İnanır, Mehmet |
| بيانات النشر: | Lippincott Williams & Wilkins |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Coronary Artery Disease, Isolated Coronary Artery Ectasia, Intestinal Permeability, Lipopolysaccharide, Low-Grade Endotoxemia, Zonulin |
| الوصف: | Purpose Isolated coronary artery ectasia (ICAE) is a rare coronary artery disease (CAD) encountered during coronary angiography. Although many mechanisms have been suggested today that may be associated with ICAE, the underlying pathogenesis has not been fully understood. In this study, we aimed to reveal the possible relationship between intestinal permeability and ICAE. Methods Of the 12 850 patients who underwent coronary angiography, 138 consecutive patients with ICAE and 140 age- and sex-matched subjects with normal coronary arteries as the control group and 140 subjects with stenotic CAD were included in the study. Results Serum zonulin and lipopolysaccharide levels were significantly higher in patients with ICAE than in the control group and CAD group. Additionally, zonulin and lipopolysaccharide levels were significantly higher in the CAD group than in the ICAE group. In the correlation analysis, serum zonulin levels were correlated with the mean diameter and length of the ecstatic segment. In multivariate analysis, zonulin and lipopolysaccharide were identified as independent predictors for ICAE. Conclusion These results suggest that there may be a pathophysiological relationship between increased intestinal permeability and ICAE. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0954-6928 1473-5830 |
| Relation: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Coronary Artery Disease; Toprak, K., Kaplangoray, M., Altiparmak, I. H., Taşcanov, M. B., Güngören, F., Fedai, H., . & Demirbağ, R. (2023). Can increased intestinal permeability and low-grade endotoxemia be the triggering pathogenesis in isolated coronary artery ectasia?. Coronary Artery Disease, 34(2), 102-110.; WOS ID :000924066800003; PUBMED ID: 36720018; http://dx.doi.org/10.1097/MCA.0000000000001209; https://hdl.handle.net/20.500.12491/11496; 34; 102; 110 |
| DOI: | 10.1097/MCA.0000000000001209 |
| الاتاحة: | https://hdl.handle.net/20.500.12491/11496 https://doi.org/10.1097/MCA.0000000000001209 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.EF2D679E |
| قاعدة البيانات: | BASE |
| تدمد: | 09546928 14735830 |
|---|---|
| DOI: | 10.1097/MCA.0000000000001209 |