Academic Journal
The ischemic/nephrotoxic acute kidney injury and the use of renal biomarkers in clinical practice
| العنوان: | The ischemic/nephrotoxic acute kidney injury and the use of renal biomarkers in clinical practice |
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| المؤلفون: | Andreucci M., Faga T., Pisani A., Perticone M., Michael A. |
| المساهمون: | Andreucci, M., Faga, T., Pisani, A., Perticone, M., Michael, A. |
| سنة النشر: | 2017 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Acute renal failure, Biomarker, Creatinine, Ischemia reperfusion, Kidney disease, Renal disease, Acid-Base Equilibrium, Acute Kidney Injury, Cystatin C, Glomerular Filtration Rate, Human, Kidney |
| الوصف: | The term Acute Renal Failure (ARF) has been replaced by the term Acute Kidney Injury (AKI). AKI indicates an abrupt (within 24–48 h) decrease in Glomerular Filtraton Rate, due to renal damage, that causes fluid and metabolic waste retention and alteration of electrolyte and acid-base balance. The renal biomarkers of AKI are substances or processes that are indicators of normal or impaired function of the kidney. The most used renal biomarker is still serum creatinine that is inadequate for several reasons, one of which is its inability to differentiate between hemodynamic changes of renal function (“prerenal azotemia”) from intrinsic renal failure or obstructive nephropathy. Cystatin C is no better in this respect. After the description of the pathophysiology of “prerenal azotemia” and of Acute Kidney Injury (AKI) due to ischemia or nephrotoxicity, the renal biomarkers are listed and described: urinary NAG, urinary and serum KIM-1, serum and urinary NGAL, urinary IL-18, urinary L-FABP, serum Midkine, urinary IGFBP7 and TIMP2, urinary α-GST and π-GST, urinary ɣGT and AP, urinary β2M, urinary RBP, serum and urinary miRNA. All have been shown to appear much earlier than the rise of serum Creatinine. Some of them have been demonstrated to predict the clinical outcomes of AKI, such as the need for initiation of dialysis and mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000402488100021; volume:39; firstpage:1; lastpage:8; numberofpages:8; journal:EUROPEAN JOURNAL OF INTERNAL MEDICINE; http://hdl.handle.net/11588/794901; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85008196952; www.elsevier.com/locate/ejim |
| DOI: | 10.1016/j.ejim.2016.12.001 |
| الاتاحة: | http://hdl.handle.net/11588/794901 https://doi.org/10.1016/j.ejim.2016.12.001 |
| رقم الانضمام: | edsbas.EF29A017 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejim.2016.12.001 |
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