Academic Journal
Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes
| العنوان: | Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes |
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| المؤلفون: | Cao, Y., Chatton, J. Y. |
| المصدر: | FEBS Letters, vol. 424, no. 1-2, pp. 33-6 |
| سنة النشر: | 1998 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals Calcium/*metabolism Calcium-Transporting ATPases/*antagonists & inhibitors Calmodulin/antagonists & inhibitors/*metabolism Enzyme Inhibitors/pharmacology Imidazoles/pharmacology Liver/cytology/*metabolism Male Rats Rats, Wistar Signal Transduction Thapsigargin/pharmacology |
| الوصف: | The possible participation of calmodulin in the activation of store-operated Ca2+ entry (SOC) in single rat hepatocytes was investigated microspectrofluorimetrically. SOC was triggered after discharging intracellular Ca2+ stores using the endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin in the absence of external Ca2+. Re-admission of bath Ca2+ caused a rapid and pronounced Ca2+ entry. The calmodulin antagonists calmidazolium or CGS 9343B applied before the thapsigargin treatment inhibited SOC, whereas they were ineffective when added after the thapsigargin-induced Ca2+ transient. This study suggests that activation of calmodulin after the elevation of cytosolic Ca2+ associated with the emptying of Ca2+ stores is involved in the triggering of SOC in hepatocytes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/9537510; info:eu-repo/semantics/altIdentifier/pissn/0014-5793; https://serval.unil.ch/notice/serval:BIB_95441CD60400 |
| DOI: | 10.1016/S0014-5793(98)00133-1 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_95441CD60400 https://doi.org/10.1016/S0014-5793(98)00133-1 |
| رقم الانضمام: | edsbas.EF03028C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0014-5793(98)00133-1 |
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