Academic Journal
Galacto‐oligosaccharides Are Bifidogenic and Safe at Weaning: A Double‐blind Randomized Multicenter Study
| العنوان: | Galacto‐oligosaccharides Are Bifidogenic and Safe at Weaning: A Double‐blind Randomized Multicenter Study |
|---|---|
| المؤلفون: | Fanaro, Silvia, Marten, Berit, Bagna, Rossana, Vigi, Vittorio, Fabris, Claudio, Peña‐Quintana, Luis, Argüelles, Federico, Scholz‐Ahrens, Katharina E, Sawatzki, Günther, Zelenka, Richard, Schrezenmeir, Jürgen, de Vrese, Michael, Bertino, Enrico |
| المصدر: | Journal of Pediatric Gastroenterology and Nutrition ; volume 48, issue 1, page 82-88 ; ISSN 0277-2116 1536-4801 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2009 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objectives: The primary objective of this study was to determine the bifidogenic effect of galacto‐oligosaccharides (GOS) in a follow‐on formula and the effects on other intestinal bacteria. Secondary objectives were the effects on stool characteristics, growth, and general well‐being. Participants and Methods: In a multicenter, double‐blind study, 159 healthy infants, formula‐fed at enrollment (at 4–6 months), were randomized to an experimental follow‐on formula supplemented with 5 g/L (GOS) (77 infants), or to a standard follow‐on formula (control, 82 infants). Infants were evaluated at enrollment (study day 1 = sd1), after 6 weeks (study day 2 = sd2), and after an additional 12 weeks (study day 3 = sd3). At each study day, a fresh stool sample for the bacterial counts was collected, and the growth parameters were measured. At sd2, urinary specimens were collected for the evaluation of urinary osmolarity. Results: At sd2 and sd3, the GOS group had a higher median number (colony‐forming units per gram of stool) of bifidobacteria than did the control group (sd2 GOS 9.2 × 10 9 vs control 4.4 × 10 9 , P = 0.012); (sd3 GOS 7.2 × 10 9 vs control 2.4 × 10 9 , P = 0.027). Other bacteria did not show any significant differences between the 2 groups at all study days. The GOS produced softer stools but had no effect on stool frequency. The urinary osmolarity (mOsm/L) at sd2 was comparable in both groups. Supplementation had no influence on the incidence of gastrointestinal side effects or on the growth of the infants. Conclusions: These data indicate that the addition of GOS (5 g/L) to a follow‐on formula positively influences the bifidobacteria flora and the stool consistency in infants during the supplementation period at weaning. No local or systemic side effects were recorded. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/mpg.0b013e31817b6dd2 |
| DOI: | 10.1097/MPG.0b013e31817b6dd2 |
| الاتاحة: | https://doi.org/10.1097/mpg.0b013e31817b6dd2 https://onlinelibrary.wiley.com/doi/pdf/10.1097/MPG.0b013e31817b6dd2 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.EEF05D35 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/mpg.0b013e31817b6dd2 |
|---|