Academic Journal
Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?
| العنوان: | Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever? |
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| المؤلفون: | Maheshi Mapalagamage, Shiroma Handunnetti, Gayani Premawansa, Sharmila Thillainathan, Tharanga Fernando, Karunayokiny Kanapathippillai, Rajitha Wickremasinghe, Aruna Dharshan De Silva, Sunil Premawansa |
| المصدر: | Disease Markers, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Potential use of total nitrite plus nitrate (NOx) and nitrite (NO2−) separately as surrogate markers for serum nitric oxide in severe dengue and their longitudinal changes along with the progression of infection was studied. Deproteinized sera from confirmed dengue fever (DF, n=145) and dengue hemorrhagic fever (DHF, n=74) patients on admission—A, critical—C, discharge—D, and convalescence—CON stages and from age-gender matched healthy individuals (HC, n=77) were taken to assess NO2− and NOx levels using Griess and modified Griess assays. Serum NOx in DHFA was significantly lower compared to DFA (p<0.001). HC had the lowest NOx and NO2− compared to all patient categories (p<0.001) except NO2− in DF-CON and DHF-CON and NOx in DHF-CON. Serum NOx and NO2− in DHF patients admitted on fever day 3 (DHFA-3) was significantly lower compared to DFA-3 (p<0.05). Cut-off values of 4.46 μM for NOx (91.3% sensitivity and 80.1% specificity) and 1.25 μM for NO2− (75.0% sensitivity and 73.3% specificity) were obtained for day 3 of fever. Serum NOx may be used as potential prognostic marker of DHF in patients presenting with DF in the early stage (on day 3 of fever) of the disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| Relation: | http://dx.doi.org/10.1155/2018/5328681; https://doaj.org/toc/0278-0240; https://doaj.org/toc/1875-8630; https://doaj.org/article/c45f5812344c465eb88179c2912cf454 |
| DOI: | 10.1155/2018/5328681 |
| الاتاحة: | https://doi.org/10.1155/2018/5328681 https://doaj.org/article/c45f5812344c465eb88179c2912cf454 |
| رقم الانضمام: | edsbas.EEEEA0EA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.1155/2018/5328681 |