Academic Journal
The cell cycle and cancer
| العنوان: | The cell cycle and cancer |
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| المؤلفون: | Williams, Gareth H, Stoeber, Kai |
| المصدر: | The Journal of Pathology ; volume 226, issue 2, page 352-364 ; ISSN 0022-3417 1096-9896 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2011 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to loss of function of tumour suppressor proteins, drives oncogenic proliferation. Gene expression profiling of these complex and redundant mitogenic pathways to identify prognostic and predictive signatures and their therapeutic targeting has, however, proved challenging. The cell cycle machinery, which acts as an integration point for information transduced through upstream signalling networks, represents an alternative target for diagnostic and therapeutic interventions. Analysis of the DNA replication initiation machinery and mitotic engine proteins in human tissues is now leading to the identification of novel biomarkers for cancer detection and prognostication, and is providing target validation for cell cycle‐directed therapies. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/path.3022 |
| الاتاحة: | https://doi.org/10.1002/path.3022 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpath.3022 https://onlinelibrary.wiley.com/doi/full/10.1002/path.3022 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.EE869131 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/path.3022 |
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