Academic Journal
Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol
| العنوان: | Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol |
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| المؤلفون: | Marietta, Marco, Vandelli, Paola, Mighali, Pasquale, Vicini, Roberto, Coluccio, Valeria, D’Amico, Roberto, COVID-19 HD Study Group |
| المصدر: | Trials, 21(1):574 |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Low-molecular weight heparin, COVID-19, Coagulopathy, Randomised controlled trial, Enoxaparin, Pneumonia, Protocol |
| الوصف: | To assess whether high doses of Low Molecular Weight Heparin (LMWH) (i.e. Enoxaparin 70 IU/kg twice daily) compared to standard prophylactic dose (i.e., Enoxaparin 4000 IU once day), in hospitalized patients with COVID19 not requiring Invasive Mechanical Ventilation [IMV], are:a)more effective in preventing clinical worsening, defined as the occurrence of at least one of the following events, whichever comes first:1.Death2.Acute Myocardial Infarction [AMI]3.Objectively confirmed, symptomatic arterial or venous thromboembolism [TE]4.Need of either:a.Continuous Positive Airway Pressure (Cpap) or Non-Invasive Ventilation (NIV) orb.IMV in patients who at randomisation were receiving standard oxygen therapy5.IMV in patients who at randomisation were receiving non-invasive mechanical ventilationb)Similar in terms of major bleeding risk |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6421652; https://doi.org/10.1186/s13063-020-04475-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316577/; https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04475-z#Sec1 |
| DOI: | 10.1186/s13063-020-04475-z |
| DOI: | 10.1186/s13063-020-04475-z#Sec1 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6421652 https://doi.org/10.1186/s13063-020-04475-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316577/ https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04475-z#Sec1 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.EE49383F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13063-020-04475-z |
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