Academic Journal
Is headache a risk factor for dementia? A systematic review and meta-analysis
| العنوان: | Is headache a risk factor for dementia? A systematic review and meta-analysis |
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| المؤلفون: | Cermelli, Aurora, Roveta, Fausto, Giorgis, Lia, Boschi, Silvia, Grassini, Alberto, Ferrandes, Fabio, Lombardo, Chiara, Marcinnò, Andrea, Rubino, Elisa, Rainero, Innocenzo |
| المساهمون: | Università degli Studi di Torino |
| المصدر: | Neurological Sciences ; volume 45, issue 3, page 1017-1030 ; ISSN 1590-1874 1590-3478 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Objective In this systematic review and meta-analysis, we critically evaluate available evidence regarding the association between primary headaches and subsequent decline of cognitive function and dementia. Background Recent studies suggested that headache disorders may increase the risk for dementia. However, available studies are conflicting. Methods To identify qualifying studies, we searched scientific databases, including Pubmed , Scopus, Web of Science, Science Direct and BMC, screening for relevant papers. In order to reduce the heterogeneity between different studies, the analyses were further subdivided according to the clinical diagnoses and the study methodologies. Results We identified 23 studies investigating the association between primary headaches and the risk of dementia. Of these, 18 met our inclusion criteria for meta-analysis (covering 924.140 individuals). Overall effect-size shows that primary headaches were associated with a small increase in dementia risk (OR = 1,15; CI 95%: 1,03–1,28; p = 0,02). Analyzing subgroups, we found that migraine was associated with both a moderate increased risk of all-cause dementia (OR = 1,26; p = 0,00; 95% CI: 1,13–1,40) as well as a moderate increased risk of Alzheimer’s disease (OR = 2,00; p = 0,00; 95% CI: 1,46–2,75). This association was significant in both case–control and retrospective cohort studies but not in prospective studies. Conclusions Our study supports the presence of a link between primary headaches and dementia. However, in the subgroup analysis, only patients with migraine showed a moderate increase risk for all-cause dementia and for Alzheimer’s disease. Additional rigorous studies are needed to elucidate the possible role of primary headaches on the risk of developing cognitive impairment and dementia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s10072-023-07069-0 |
| DOI: | 10.1007/s10072-023-07069-0.pdf |
| DOI: | 10.1007/s10072-023-07069-0/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s10072-023-07069-0 https://link.springer.com/content/pdf/10.1007/s10072-023-07069-0.pdf https://link.springer.com/article/10.1007/s10072-023-07069-0/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.EE288EE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10072-023-07069-0 |
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