Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)

التفاصيل البيبلوغرافية
العنوان:	Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)
المؤلفون:	Chen, Rui, Zhou, Li-Qun, Cai, Xiao-Bing, Xie, Li-Ping, Huang, Yi-Ran, He, Da-Lin, Gao, Xu, Xu, Chuan-Liang, Ding, Qiang, Wei, Qiang, Yin, Chang-Jun, Ren, Shan-Cheng, Wang, Fu-Bo, Tian, Ye, Sun, Zhong-Quan, Fu, Qiang, Ma, Lu-Lin, Zheng, Jun-Hua, Ye, Zhang-Qun, Ye, Ding-Wei, Xu, Dan-Feng, Hou, Jian-Quan, Xu, Ke-Xin, Yuan, Jian-Lin, Gao, Xin, Liu, Chun-Xiao, Pan, Tie-Jun, Sun, Ying-Hao
المساهمون:	Sun, YH (reprint author), Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China., Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China., Peking Univ, Inst Urol, Dept Urol, Hosp 1,Natl Urol Canc Ctr, Beijing 100034, Peoples R China., PLA Headquarters Gen Staff Guard Bur, Dept Hlth Care, Beijing 100017, Peoples R China., Zhejiang Univ, Sch Med, Dept Urol, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China., Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, Shanghai 200127, Peoples R China., Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Xian 710061, Peoples R China., Fudan Univ, Huashan Hosp, Dept Urol, Shanghai 200040, Peoples R China., Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China., Nanjing Med Univ, Dept Urol, State Key Lab Reprod Med, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China., Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China., Fudan Univ, Huadong Hosp, Dept Urol, Shanghai 20040, Peoples R China., Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Urol, Shanghai 200233, Peoples R China., Peking Univ, Hosp 3, Dept Urol, Beijing 100083, Peoples R China., Tongji Univ, Peoples Hosp 10, Dept Urol, Shanghai 200072, Peoples R China., Huazhong Univ Sci & Technol, Tongji Hosp, Dept Urol, Tongji Med Coll, Wuhan 430030, Peoples R China., Fudan Univ, Dept Oncol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China., Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Urol, Shanghai 200003, Peoples R China., Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Peoples R China., Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China., Fourth Mil Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Peoples R China., Sun Yat Sen Univ, Hosp 3, Dept Urol, Guangzhou 510630, Guangdong, Peoples R China., Southern Med Univ, Zhujiang Hosp, Dept Urol, Guangzhou 510282, Guangdong, Peoples R China., Guangzhou Mil Command, Wuhan Gen Hosp, Dept Urol, Wuhan 430070, Peoples R China.
المصدر:	SCI ; CSCD
بيانات النشر:	ASIAN JOURNAL OF ANDROLOGY
سنة النشر:	2015
المجموعة:	Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
مصطلحات موضوعية:	Chinese population, diagnosis, percent free prostate-specific antigen, prostate cancer, prostate carcinoma tumor antigen, prostate-specific antigen, MULTICENTER CLINICAL-TRIAL, DIGITAL RECTAL EXAMINATION, GENOME-WIDE ASSOCIATION, FREE PSA, CANCER DETECTION, SERUM-LEVELS, NG/ML, METAANALYSIS, PERFORMANCE, POPULATION
الوصف:	Percent free prostatic-specific antigen (%fPSA) has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml(1) , however, it remains controversial whether %fPSA is effective in PSA range of 10.1-20.0 ng ml(1) in both Chinese and Western population. In this study, the diagnostic performance of %fPSA and serum PSA in predicting prostate cancer (PCa) and high-grade PCa (HGPCa) was analyzed in a multi-center biopsy cohort of 5915 consecutive Chinese patients who underwent prostate biopsy in 22 hospitals across China from January 1, 2010 to December 31, 2013. The indication for biopsy was PSA > 4.0 ng ml(1) or/and suspicious digital rectal examination. Total and free serum PSA determinations were performed by three types of electrochemiluminescence immunoassays with recalibration to the World Health Organization standards. The diagnostics accuracy of PSA, %fPSA and %fPSA in combination with PSA (%fPSA PSA) was determined by the area under the receivers operating characteristic curve (AUC). %fPSA was more effective than PSA in men aged >= 60 years old. The AUC was 0.584 and 0.635 in men aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) , respectively. The AUC of %fPSA was superior to that of PSA in predicting HGPCa in patients >= 60 years old in these two PSA range. Our results indicated that %fPSA is both statistically effective and clinical applicable to predict prostate biopsy outcome in Chinese patients aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) . ; Chinese Prostate Cancer Consortium, Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China [IRT1111]; National Basic Research Program of China [2012CB518300, 2012CB518306] ; SCI(E) ; 中国科技核心期刊(ISTIC) ; 中国科学引文数据库(CSCD) ; ARTICLE ; sunyh@medmail.com.cn ; 6 ; 1017-1021 ; 17
نوع الوثيقة:	journal/newspaper
اللغة:	English
تدمد:	1008-682X 1745-7262
Relation:	ASIAN JOURNAL OF ANDROLOGY.2015,17,(6),1017-1021.; 1400439; http://hdl.handle.net/20.500.11897/439296; WOS:000366040100030
DOI:	10.4103/1008-682X.150846
الاتاحة:	https://hdl.handle.net/20.500.11897/439296 https://doi.org/10.4103/1008-682X.150846
رقم الانضمام:	edsbas.EDFCBFA3
قاعدة البيانات:	BASE

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الوصف
تدمد:	1008682X 17457262
DOI:	10.4103/1008-682X.150846