التفاصيل البيبلوغرافية
| العنوان: |
Deletion of Col15a1 modulates the tumour extracellular matrix and leads to increased tumour growth in the MMTV-PyMT mouse mammary carcinoma model |
| المؤلفون: |
Martínez-Nieto, G. (Guillermo), Heljasvaara, R. (Ritva), Heikkinen, A. (Anne), Kaski, H.-K. (Hanne-Kaisa), Devarajan, R. (Raman), Rinne, O. (Otto), Henriksson, C. (Charlotta), Thomson, E. (Emmi), von Hertzen, C. (Camilla), Miinalainen, I. (Ilkka), Ruotsalainen, H. (Heli), Pihlajaniemi, T. (Taina), Karppinen, S.-M. (Sanna-Maria) |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
ECM remodelling, MMTV-PyMT, angiogenesis, breast cancer, collagen XV, fibrosarcoma, restin, syngeneic tumour models, tumour stroma |
| الوصف: |
Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost from the epithelial BM zone prior to tumour invasion. Here, we addressed the roles of ColXV in breast carcinogenesis using the transgenic MMTV-PyMT mouse mammary carcinoma model. We show here for the first time that the inactivation of Col15a1 in mice leads to changes in the fibrillar tumour matrix and to increased mammary tumour growth. ColXV is expressed by myoepithelial and endothelial cells in mammary tumours and is lost from the ductal BM along with the loss of the myoepithelial layer during cancer progression while persisting in blood vessels and capillaries, even in invasive tumours. However, despite the absence of anti-angiogenic restin domain, neovascularisation was reduced rather than increased in the ColXV-deficient mammary tumours compared to controls. We also show that, in robust tumour cell transplantation models or in a chemical-induced fibrosarcoma model, the inactivation of Col15a1 does not affect tumour growth or angiogenesis. In conclusion, our results support the proposed tumour suppressor function of ColXV in mammary carcinogenesis and reveal diverse roles of this collagen in different cancer types |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
info:eu-repo/grantAgreement/EC/FP7/316610/EU/Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion/CAFFEIN |
| الاتاحة: |
http://urn.fi/urn:nbn:fi-fe2021102852807 |
| Rights: |
info:eu-repo/semantics/openAccess ; © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.EDED01A1 |
| قاعدة البيانات: |
BASE |