Academic Journal
Race-free estimated glomerular filtration rate equation in kidney transplant recipients:development and validation study
| العنوان: | Race-free estimated glomerular filtration rate equation in kidney transplant recipients:development and validation study |
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| المؤلفون: | Raynaud, Marc, Al-Awadhi, Solaf, Juric, Ivana, Divard, Gillian, Lombardi, Yannis, Basic-Jukic, Nikolina, Aubert, Olivier, Dubourg, Laurence, Masson, Ingrid, Mariat, Christophe, Prié, Dominique, Pernin, Vincent, Le Quintrec, Moglie, Larson, Timothy S, Stegall, Mark D, Bikbov, Boris, Ruggenenti, Piero, Mesnard, Laurent, Ibrahim, Hassan N, Nielsen, Marie Bodilsen, Matas, Arthur J, Nankivell, Brian J, Benjamens, Stan, Pol, Robert A, Bakker, Stephan J L, Jouven, Xavier, Legendre, Christophe, Kamar, Nassim, Smith, Byron H, Wadei, Hani M, Durrbach, Antoine, Vincenti, Flavio, Remuzzi, Giuseppe, Lefaucheur, Carmen, Bentall, Andrew J, Loupy, Alexandre |
| المصدر: | Raynaud , M , Al-Awadhi , S , Juric , I , Divard , G , Lombardi , Y , Basic-Jukic , N , Aubert , O , Dubourg , L , Masson , I , Mariat , C , Prié , D , Pernin , V , Le Quintrec , M , Larson , T S , Stegall , M D , Bikbov , B , Ruggenenti , P , Mesnard , L , Ibrahim , H N , Nielsen , M B , Matas , A J , Nankivell , B J , Benjamens , S , .... |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Adult, Humans, Glomerular Filtration Rate, Kidney Transplantation, Creatinine, Kidney, Renal Insufficiency, Chronic/diagnosis |
| الوصف: | OBJECTIVE: To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the three current main equations for measuring GFR in kidney transplant recipients. DESIGN: Development and validation study SETTING: 17 cohorts in Europe, the United States, and Australia (14 transplant centres, three clinical trials). PARTICIPANTS: 15 489 adults (3622 in development cohort (Necker, Saint Louis, and Toulouse hospitals, France), 11 867 in multiple external validation cohorts) who received kidney transplants between 1 January 2000 and 1 January 2021. MAIN OUTCOME MEASURE: The main outcome measure was GFR, measured according to local practice. Performance of the GFR equations was assessed using P 30 (proportion of estimated GFR (eGFR) within 30% of measured GFR (mGFR)) and correct classification (agreement between eGFR and mGFR according to GFR stages). The race-free equation, based on creatinine level, age, and sex, was developed using additive and multiplicative linear regressions, and its performance was compared with the three current main GFR equations: Modification of Diet in Renal Disease (MDRD) equation, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 equation, and race-free CKD-EPI 2021 equation. RESULTS: The study included 15 489 participants, with 50 464 mGFR and eGFR values. The mean GFR was 53.18 mL/min/1.73m 2 (SD 17.23) in the development cohort and 55.90 mL/min/1.73m 2 (19.69) in the external validation cohorts. Among the current GFR equations, the race-free CKD-EPI 2021 equation showed the lowest performance compared with the MDRD and CKD-EPI 2009 equations. When race was included in the kidney recipient specific GFR equation, performance did not increase. The race-free kidney recipient specific GFR equation showed significantly improved performance compared with the race-free CKD-EPI 2021 equation and performed well in the external validation cohorts (P 30 ranging from 73.0% to 91.3%). The race-free kidney recipient ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1136/bmj-2022-073654 |
| الاتاحة: | https://hdl.handle.net/11370/dab62753-b4cc-4272-bf3d-3f8a5f4a06d1 https://research.rug.nl/en/publications/dab62753-b4cc-4272-bf3d-3f8a5f4a06d1 https://doi.org/10.1136/bmj-2022-073654 https://pure.rug.nl/ws/files/721117289/bmj-2022-073654.full.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EDE63331 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmj-2022-073654 |
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