Academic Journal
A standard numbering scheme for class C β-lactamases
| العنوان: | A standard numbering scheme for class C β-lactamases |
|---|---|
| المؤلفون: | Mack, AR, Barnes, MD, Taracila, MA, Hujer, AM, Hujer, KM, Cabot, G, Feldgarden, M, Haft, DH, Klimke, W, van den Akker, F, Vila, AJ, Smania, A, Haider, S, Papp-Wallace, KM, Bradford, PA, Rossolini, GM, Docquier, J-D, Frère, J-M, Galleni, M, Hanson, ND, Oliver, A, Plésiat, P, Poirel, L, Nordmann, P, Palzkill, TG, Jacoby, GA, Bush, K, Bonomo, RA |
| المصدر: | Antimicrobial Agents and Chemotherapy (2019) (In press). |
| سنة النشر: | 2019 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | Unlike classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered, and includes a variation for genetic and epidemiological applications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10086472/4/Shozeb%20AmpC-Numbering-Manuscript_Revision_Final.pdf; https://discovery.ucl.ac.uk/id/eprint/10086472/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10086472/4/Shozeb%20AmpC-Numbering-Manuscript_Revision_Final.pdf https://discovery.ucl.ac.uk/id/eprint/10086472/ |
| Rights: | open |
| رقم الانضمام: | edsbas.ED80FC81 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |