التفاصيل البيبلوغرافية
| العنوان: |
Additional file 1 of Remote-controllable bone-targeted delivery of estradiol for the treatment of ovariectomy-induced osteoporosis in rats |
| المؤلفون: |
Yuanyuan Guo (50344), Yongwei Liu (8086988), Chen Shi (415895), Tingting Wu (228837), Yongzhi Cui (388541), Siyuan Wang (147000), Ping Liu (156158), Xiaobo Feng (2183406), Yu He (420536), Dehao Fu (11294709) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Physiology, Biotechnology, Ecology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, bone-targeted multifunctional NPs, BV, bone tissue destruction, Remote-controllable bone-targeted d., CTX, OC, side effects, 3O, remote-controllable drug release, AL, Hormone replacement therapy, OP, bone mass reduction, Raw 264.7 cells, rats Abstract Background Osteoporosis, particle size, PLGA, field ameliorated OVX-induced bone loss, TRAP, co-load 17β estradiol, PINP |
| الوصف: |
Additional file 1: Table S1. Encapsulation efficiency (EE%) and drug loading efficiency (DLE%) of estradiol in PLGA@E2 NPs, AL-PLGA@E2 NPs, PEG-PLGA@E2 NPs and PEG-PLGA-AL@E2 NPs. Table S2. EE% and DLE% of estradiol in PEG-PLGA-AL@E2 NPs. Table S3. The characteristics of PEG-PLGA-AL@ Fe3O4/E2 NPs. Figure S1. Synthesis of AL-PLGA. Synthetic scheme (a) and associated 1H-NMR spectra of PLGA (b) and AL-PLGA (c). Figure S2. In vitro particle stability assay of PEG-PLGA-AL@Fe3O4/E2 NPs in 1×PBS or FBS. Figure S3. The effect of NPs on WBC, RBC, HGB and PLT at end of study (week 13). Figure S4. The effect of NPs on ALT, AST, ALP, Cr and TC in sham and OVX rats at end of study (week 13). Figure S5. Sections of main organs were obtained and stained with H&E. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Additional_file_1_of_Remote-controllable_bone-targeted_delivery_of_estradiol_for_the_treatment_of_ovariectomy-induced_osteoporosis_in_rats/15253815 |
| DOI: |
10.6084/m9.figshare.15253815.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.15253815.v1 |
| Rights: |
CC BY + CC0 |
| رقم الانضمام: |
edsbas.ED7B802 |
| قاعدة البيانات: |
BASE |