التفاصيل البيبلوغرافية
| العنوان: |
Manipulations of each hit tuned diabetes progression. |
| المؤلفون: |
Fan Yu (513775), Xian Zhou (405014), Xiang Jin (402181), Shushu Zhao (11984824), Gan Zhao (4789428), Sheng Jiang (303820), Shuang Geng (176956), Bin Wang (30851) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Cell Biology, Genetics, Neuroscience, Immunology, Marine Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >+, refined temporal analysis, real pathological course, hit second time, cell dominant infiltrates, cell depletion ), mouse data fail, human autoimmune diabetes, obesity diabetes model, div >< p, hit ’ strategy, first hit, cell responses, mouse models, human disease, nod model, improvised model, ‘ double, unleash auto, transient immune |
| الوصف: |
a . Pancreas damage severity affected diabetes progression. Left, multiple low-dose STZ schedules. In addition to standard 3*STZ+DT schedule (Red), stronger (5*STZ+DT, magenta) or weaker (2*STZ+DT, orange, or 1*STZ+DT, yellow) STZ damage schedules were analyzed. Right, blood glucose fluctuation after model setup. DT was given as control (Black). Arrow represents model setup from day -5 to day 0. Dash line represents blood glucose at 16.7 mmol/L. n = 5. N = 3. b . Survival after diabetes onset. Color codes as in 4a. n = 5. c-e . Autoimmune severity affected diabetes progression. c . Genotype of homozygous and heterozygous DEREG mice. Wildtype littermates were added as negative control. Numbers showed Foxp3 + GFP-DTR - Treg percentage in CD4 + spleno-T cells, analyzed by intracellular staining. n = 3. N = 3. d. Foxp3 + Treg dynamic after DT depletion of DTR + Tregs. Statistical significance was analyzed between homozygous (Red) and heterozygous (Brown) groups at day 1, 6 and 12. n = 6. N = 3. e . Blood glucose fluctuation after model setup in homozygous or heterozygous DEREG mice. Blood glucose over 16.7 mmol/L was identified as hyperglycemia (Dash line). Statistics between Homozygous and Heterozygous mice were shown for each testing day. n = 6. N = 3. f Disease onset date of 1 st hit or 2 nd hit manipulations. 1 st hit manipulation was compared between 5*STZ+DT (magenta) and 3*STZ+DT (red) groups, both in homozygous DEREG mice. 2 nd hit manipulations was compared between homozygous (Red) and heterozygous (Brown) DEREG mice, both under 3*STZ+DT standard schedule. Batch effects were also calculated within the same schedule. n = 4~6. g . Disease onset date of two batches of NOD mice. n = 7. *, p < 0.05; **, p < 0.01. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/Manipulations_of_each_hit_tuned_diabetes_progression_/18859030 |
| DOI: |
10.1371/journal.pone.0260100.g004 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0260100.g004 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.ED69DD75 |
| قاعدة البيانات: |
BASE |