Academic Journal
Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients
| العنوان: | Xenobiotic/drug metabolizing enzyme and TP53 polymorphisms and clinical outcome in advanced nonsmall cell lung cancer patients |
|---|---|
| المؤلفون: | KARACAOĞLAN, Volkan, ADA, Ahmet Oğuz, BİLGEN, Serdar, ÇETİNKAYA, Güzide Tuğba, SOYDAŞ, Emre, KUNAK, Celalettin Semih, ALPAR, Sibel Meryem, GÜLHAN, Meral, İŞCAN, Mümtaz |
| المصدر: | Volume: 47, Issue: 2 554-562 ; 1300-0144 ; 1303-6165 ; Turkish Journal of Medical Sciences |
| بيانات النشر: | TÜBİTAK TUBITAK |
| سنة النشر: | 2017 |
| المجموعة: | DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: | Xenobiotic/drug metabolizing enzymes,TP53,polymorphisms,response to chemotherapy,survival,nonsmall cell lung cancer |
| الوصف: | Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P = 0.066). We also analyzed these gene variants in combination with CYP1A1 (Ile462Val), CYP1B1 (Asn453Ser), GSTM1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) and GSTT1 polymorphic genes that we have previously genotyped in the same patients (Ada et al., Neoplasma, 57, 512-527, 2010). The multivariate analysis revealed that adjusted hazard ratio (HR) of death of the combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile462Val, Val462Val) increased significantly as compared to wild-type genotypes (HR, 6.03; 95% CI, 1.39-26.04, P = 0.016). Conclusion: These results show that combined variant genotypes of TP53 (Arg72Pro, Pro72Pro) and CYP1A1 (Ile/Val, Val/Val) are associated with worsening of survival in NSCLC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://dergipark.org.tr/tr/download/article-file/733483; https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45678/576111 |
| الاتاحة: | https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45678/576111 |
| رقم الانضمام: | edsbas.ED51D5E3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |