Academic Journal
Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6
| العنوان: | Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6 |
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| المساهمون: | Katsutoshi Ozaki, Rosanne Spolski, Warren J. Leonard, Peter E. Lipsky, Herbert C. Morse, Derry C. Roopenian, Shreeram Akilesh, Daniel J. Shaffer, Patrick Hwu, Chen-Feng Qi, Gang Wang, Hyoung-Pyo Kim, Rachel Ettinger, Kim, Hyoung Pyo |
| المصدر: | T200404375.pdf |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Animals, Apoptosis/genetics, Apoptosis/immunology, B-Lymphocyte Subsets/cytology, B-Lymphocyte Subsets/immunology, B-Lymphocyte Subsets/metabolism, Cell혻Division/genetics, Cell혻Division/immunology, Cell혻Separation, Cells, Cultured, DNA-Binding Proteins/antagonists & inhibitors, DNA-Binding Proteins/biosynthesis, Humans, Immunoglobulin Class Switching/genetics, Interleukins/biosynthesis, Interleukins/genetics, Interleukins/physiology, Lupus Erythematosus, Systemic/genetics, Systemic/immunology, Lymphocyte Count, Membrane Glycoproteins/biosynthesis, Mice, Inbred C57BL, Knockout, Mutant Strains, Transgenic, PAX5 Transcription Factor, Plasma혻Cells/cytology |
| الوصف: | IL-21 is a type I cytokine whose receptor is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Using IL-21-transgenic mice and hydrodynamics-based gene delivery of IL-21 plasmid DNA into wild-type mice as well as in vitro studies, we demonstrate that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells. Thus, IL-21 differentially influences B cell fate depending on the signaling context, explaining how IL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo. Moreover, we demonstrate that IL-21 unexpectedly induces expression of both Blimp-1 and Bcl-6, indicating mechanisms as to how IL-21 can serve as a complex regulator of B cell maturation and terminal differentiation. Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 5361~5371 |
| اللغة: | unknown |
| تدمد: | 0022-1767 1550-6606 |
| Relation: | JOURNAL OF IMMUNOLOGY; J01450; OAK-2004-01867; https://ir.ymlib.yonsei.ac.kr/handle/22282913/112946; T200404375; JOURNAL OF IMMUNOLOGY, Vol.173(9) : 5361-5371, 2004 |
| DOI: | 10.4049/�땕immunol.173.9.5361 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112946 https://doi.org/10.4049/�땕immunol.173.9.5361 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; free |
| رقم الانضمام: | edsbas.ED2297AD |
| قاعدة البيانات: | BASE |
| تدمد: | 00221767 15506606 |
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| DOI: | 10.4049/�땕immunol.173.9.5361 |