Academic Journal
Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features
| العنوان: | Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features |
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| المؤلفون: | Benabou, Eva, Salamé, Zeina, Wendum, Dominique, Lequoy, Marie, Tahraoui, Sylvana, Merabtene, Fatiha, Chrétien, Yves, Scatton, Olivier, Rosmorduc, Olivier, Fouassier, Laura, Fartoux, Laetitia, Praz, Françoise, Desbois-Mouthon, Christèle |
| المساهمون: | Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité Mixte de Service d'Imagerie et de Cytométrie (UMS LUMIC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière AP-HP |
| المصدر: | ISSN: 0304-3835 ; Cancer Letters ; https://hal.sorbonne-universite.fr/hal-02271740 ; Cancer Letters, 2019, 450, pp.155-168. ⟨10.1016/j.canlet.2019.02.037⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | INSR, Liver cancer, Invasion, Cytokeratin-19, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| الوصف: | International audience ; Hepatocellular carcinoma (HCC) is one of the most common and deadly neoplasms. Insulin receptor (IR) exists in two isoforms, IR-A and IR-B, the latter being predominantly expressed in normal adult hepatocytes while IR-A is overexpressed in HCC to the detriment of IR-B. This study evaluated the biological functions associated with IR-A overexpression in HCC in relation to expression of its ligand IGF-II. The value of INSRA:INSRB ratio which was increased in ˜70% of 85 HCC was associated with stem/progenitor cell features such as cytokeratin-19 and α-fetoprotein and correlated with shorter patient survival. IGF2 mRNA upregulation was observed in 9.4% of HCC and was not associated with higher INSRA:INSRB ratios. Ectopic overexpression of IR-A in two HCC cell lines presenting a strong autocrine IGF-II secretion loop or not stimulated cell migration and invasion. In cells cultured as spheroids, IR-A overexpression promoted gene programs related to stemness, inflammation and cell movement. IR-A also increased cell line tumorigenicity in vivo after injection to immunosuppressed mice and the sphere-forming cells made a significant contribution to this effect. Altogether, these results demonstrate that IR-A is a novel player in HCC progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30849481; PUBMED: 30849481 |
| DOI: | 10.1016/j.canlet.2019.02.037 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-02271740 https://hal.sorbonne-universite.fr/hal-02271740v1/document https://hal.sorbonne-universite.fr/hal-02271740v1/file/Benabou%20accepted%20HAL.pdf https://doi.org/10.1016/j.canlet.2019.02.037 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.ECF9DF38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.canlet.2019.02.037 |
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