Academic Journal
Prognostic Nutritional Index Predicts Outcome of PD‐L1 Negative and MSS Advanced Cancer Treated with PD‐1 Inhibitors
| العنوان: | Prognostic Nutritional Index Predicts Outcome of PD‐L1 Negative and MSS Advanced Cancer Treated with PD‐1 Inhibitors |
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| المؤلفون: | Zhang, Yan, Jin, Jun, Tang, Min, Li, Ping, Zhou, Li-Na, Du, Yi-Ping, Chen, Min-Bin |
| المساهمون: | Suda, Kenichi, Scientific and technological projects of Suzhou |
| المصدر: | BioMed Research International ; volume 2022, issue 1 ; ISSN 2314-6133 2314-6141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Purpose . Tumor mutational burden (TMB), microsatellite instability‐high (MSI‐H), and expression of programmed death ligand‐1 (PD‐L1) have emerged as predictive biomarkers for responsiveness to immune checkpoint inhibitors (ICIs) in several cancer types. However, for patients with negative PD‐L1 expression, or microsatellite stability (MSS), some cases may experience favorable response to immunotherapy, and there is currently a lack of good relevant predictors. We tried to introduce several peripheral blood markers for predicting treatment outcome and immune‐related adverse events (irAEs) in PD‐L1 negative and MSS patients. Methods . A retrospective study of 142 PD‐L1 negative and MSS patients was carried out. The association of peripheral blood markers including lactate dehydrogenase (LDH), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), albumin‐to‐globulin ratio (AGR), prognostic nutrition index (PNI), and other factors with clinicopathological characters and prognosis were assessed by Cox regression and Kaplan‐Meier methods. Results . Lower level of PNI and poor performance status (ECOG score of 2) was correlated with significantly shorter overall survival (OS) and worse outcome of ICIs. The multivariate analysis revealed that PNI (for OS HR = 0.465, 95% CI: 0.236–0.916, p = 0.027; for PFS HR = 0.493, 95% CI: 0.251–0.936, p = 0.031) and ECOG score (for OS HR = 4.601, 95% CI: 2.676–7.910, p < 0.001; for PFS HR = 2.830, 95% CI: 1.707–4.691, p < 0.001) were independent prognostic factors for OS and PFS. NLR was related to the onset of irAEs. Conclusions . Pretreatment level of PNI and NLR, beyond PD‐L1 expression and MSS, can improve the predictive accuracy for immunotherapy outcomes and has the potential to expand the candidate pool of patients for treatment with ICIs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2022/6743126 |
| الاتاحة: | https://doi.org/10.1155/2022/6743126 http://downloads.hindawi.com/journals/bmri/2022/6743126.pdf http://downloads.hindawi.com/journals/bmri/2022/6743126.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2022/6743126 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.ECF31A40 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2022/6743126 |
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