التفاصيل البيبلوغرافية
| العنوان: |
Exploration of matrix effects in laser ablation inductively coupled plasma mass spectrometry imaging of cisplatin treated tumors |
| المؤلفون: |
Calum Greenhalgh, Ellie Karekla, Gareth J Miles, Ian R Powley, Catia Costa, Janella de Jesus, Melanie Jane Bailey, Catrin Pritchard, Marion MacFarlane, J Howard Pringle, Amy Managh |
| سنة النشر: |
2020 |
| المجموعة: |
Loughborough University: Figshare |
| مصطلحات موضوعية: |
Uncategorized, Analytical Chemistry, Other Chemical Sciences |
| الوصف: |
The use of a low aerosol dispersion ablation chamber within a LA-ICP-MS set up allows for high-resolution, high-speed imaging of the distribution of elements within a sample. Here we show how this enhanced capability creates new analytical problems and solutions. We report the distribution of platinum at the cellular level in non-small cell lung cancer (NSCLC) explant models after treatment with clinically relevant doses of cisplatin. This revealed for the first time a correlation between the platinum signal and the presence of carbon deposits within lung tissue. We show how complementary ion beam analysis techniques, particle induced X-ray emission (PIXE) and elastic backscattering spectrometry (EBS) can be used to explore potential matrix effects in LA-ICP-MS data. For these samples, it was confirmed that the enhancement was unlikely to have resulted from a matrix effect alone. Thus, the presence of carbon deposits within tissue has potential implications for the effective distribution of the cisplatin drug. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
2134/12555839.v1; https://figshare.com/articles/journal_contribution/Exploration_of_matrix_effects_in_laser_ablation_inductively_coupled_plasma_mass_spectrometry_imaging_of_cisplatin_treated_tumors/12555839 |
| الاتاحة: |
https://figshare.com/articles/journal_contribution/Exploration_of_matrix_effects_in_laser_ablation_inductively_coupled_plasma_mass_spectrometry_imaging_of_cisplatin_treated_tumors/12555839 |
| Rights: |
CC BY-NC-ND 4.0 |
| رقم الانضمام: |
edsbas.ECDCE3C |
| قاعدة البيانات: |
BASE |