Academic Journal
AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.
| العنوان: | AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model. |
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| المؤلفون: | Cochez, Perrine, Michiels, Camille, Hendrickx, Emilie, Van Belle, Astrid B, Lemaire, Muriel M, Dauguet, Nicolas, Warnier, Guy, de Heusch, Magali, Togbe, Dieudonnée, Ryffel, Bernhard, Coulie, Pierre, Renauld, Jean-Christophe, Dumoutier, Laure |
| المساهمون: | UCL - SSS/DDUV - Institut de Duve |
| المصدر: | European Journal of Immunology, Vol. 46, no.6, p. 1449-1459 (2016) |
| بيانات النشر: | Wiley - V C H Verlag GmbH & Co. KGaA |
| سنة النشر: | 2016 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| الوصف: | IL-22 has a detrimental role in skin inflammatory processes, for example in psoriasis. As transcription factor, AhR controls the IL-22 production by several cell types (i.e. Th17 cells). Here, we analyzed the role of Ahr in IL-22 production by immune cells in the inflamed skin, using an imiquimod-induced psoriasis mouse model. Our results indicate that IL-22 is expressed in the ear of imiquimod-treated Ahr(-/-) mice but less than in wild-type mice. We then studied the role of AhR on three cell populations known to produce IL-22 in the skin: γδ T cells, Th17 cells, and ILC3, and a novel IL-22-producing cell type identified in this setting: CD4(-) CD8(-) TCRβ(+) T cells. We showed that AhR is required for IL-22 production by Th17, but not by the three other cell types, in the imiquimod-treated ears. Moreover, AhR has a role in the recruitment of γδ T cells, ILC3, and CD4(-) CD8(-) TCRβ(+) T cells into the inflamed skin or in their local proliferation. Taken together, AhR has a direct role in IL-22 production by Th17 cells in the mouse ear skin, but not by γδ T cells, CD4(-) CD8(-) TCRβ(+) T cells and ILCs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0014-2980 1521-4141 |
| Relation: | boreal:175172; http://hdl.handle.net/2078.1/175172; info:pmid/27000947; urn:ISSN:0014-2980; urn:EISSN:1521-4141 |
| DOI: | 10.1002/eji.201546070 |
| الاتاحة: | http://hdl.handle.net/2078.1/175172 https://doi.org/10.1002/eji.201546070 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.ECDBA94E |
| قاعدة البيانات: | BASE |
| تدمد: | 00142980 15214141 |
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| DOI: | 10.1002/eji.201546070 |