التفاصيل البيبلوغرافية
| العنوان: |
Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2 |
| المؤلفون: |
Roya Zandi, Jessica Song, Paul S. Micevych, Amani A. Fawzi |
| المصدر: |
Journal of Clinical Medicine; Volume 9; Issue 10; Pages: 3149 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
optical coherence tomography angiography, optical coherence tomography, adaptive optics scanning laser ophthalmoscopy, photoreceptors, macular telangiectasia, retinal imaging analysis |
| الوصف: |
In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as “photoreceptor lesions”. En-face OCTA images of the deep capillary plexus (DCP) were used in conjunction with confocal AOSLO to evaluate the topographic relationship between areas of capillary telangiectasias and photoreceptor lesions. Among seven eyes with early stage MacTel (stage 0–2 based on OCT), we identified ten photoreceptor lesions, all of which were located within parafoveal quadrants containing DCP telangiectasia on OCTA. Seven of the lesions corresponded to the intact ellipsoid zone on spectral-domain OCT (SD-OCT), and three of these also corresponded to the intact interdigitation zone. This work demonstrates a topographic relationship between AOSLO photoreceptor lesions and DCP telangiectasias, and it also suggests that these lesions with normal SD-OCT appearance may represent areas of photoreceptors at risk for dysfunction. Thus, confocal AOSLO may have a meaningful role in detecting early photoreceptor abnormalities in eyes with MacTel. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Ophthalmology; https://dx.doi.org/10.3390/jcm9103149 |
| DOI: |
10.3390/jcm9103149 |
| الاتاحة: |
https://doi.org/10.3390/jcm9103149 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.ECCD9B03 |
| قاعدة البيانات: |
BASE |