Academic Journal
Helicobacter pylori Vacuolating Toxin and Gastric Cancer
| العنوان: | Helicobacter pylori Vacuolating Toxin and Gastric Cancer |
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| المؤلفون: | Mark S. McClain, Amber C. Beckett, Timothy L. Cover |
| المصدر: | Toxins, Vol 9, Iss 10, p 316 (2017) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Helicobacter pylori, gastric cancer, pore-forming toxins, Medicine |
| الوصف: | Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6651 |
| Relation: | https://www.mdpi.com/2072-6651/9/10/316; https://doaj.org/toc/2072-6651; https://doaj.org/article/632c0f2f9c59489cab0382bce523513e |
| DOI: | 10.3390/toxins9100316 |
| الاتاحة: | https://doi.org/10.3390/toxins9100316 https://doaj.org/article/632c0f2f9c59489cab0382bce523513e |
| رقم الانضمام: | edsbas.ECC96E8B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726651 |
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| DOI: | 10.3390/toxins9100316 |