التفاصيل البيبلوغرافية
| العنوان: |
Pharmacokinetics and Oral Bioavailability of Panax Notoginseng Saponins Administered to Rats Using a Validated UPLC–MS/MS Method |
| المؤلفون: |
Xinzhen Fu (9201722), Kun Chen (131048), Zhi Li (72309), Huaying Fan (6183848), Bo Xu (233514), Ming Liu (105953), Lin Guo (113004), Zeping Xie (543927), Ke Liu (121889), Shumin Zhang (187205), Lijuan Kou (12644243) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biochemistry, Cell Biology, Genetics, Pharmacology, Cancer, Mental Health, Plant Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, important bioactive components, five major saponins, five main ingredients, total oral bioavailability, oral absolute bioavailability, major pns metabolites, 8 %), rg1, 4 %), r1, oral bioavailability, 5 %), significantly different, results demonstrated, rats using, pns exposure, oral administration, ms system, following intravenous, determined using |
| الوصف: |
Panax notoginseng saponins (PNS) are the most important bioactive components of P. Notoginseng. In this paper, an evaluation of the pharmacokinetics and oral absolute bioavailability of PNS was carried out following intravenous and oral administration of PNS to Sprague–Dawley rats. The plasma concentration of 28 PNS was determined using a validated UPLC–MS/MS system. The results demonstrated that Rb1(32.8%), Rg1(41.4%), R1(9.4%), Re(4.5%), and Rd(3.5%) are the five main ingredients of PNS for administration. After oral administration, it was found that the area under the curve (AUC 0–72 h ) for these five major saponins was significantly different. AUC 0–72 h of Rb1 and Rd accounted for about 60% of all PNS exposure, while AUC 0–72 h of Rg1 and R1 only accounted for 0.7%, and Re was undetectable in plasma. Also, PPD, PPT, and CK were detected as the major PNS metabolites in vivo. Furthermore, it was shown that the total oral bioavailability of PNS was only 1.2%. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Pharmacokinetics_and_Oral_Bioavailability_of_Panax_Notoginseng_Saponins_Administered_to_Rats_Using_a_Validated_UPLC_MS_MS_Method/21786504 |
| DOI: |
10.1021/acs.jafc.2c06312.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.jafc.2c06312.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.ECB0BE6 |
| قاعدة البيانات: |
BASE |