Academic Journal
The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation
| العنوان: | The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation |
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| المؤلفون: | Do Luong Huynh, Nisansala Chandimali, Jiao Jiao Zhang, Nameun Kim, Yang Ho Park, Taeho Kwon, Dong Kee Jeong |
| المصدر: | Evidence-Based Complementary and Alternative Medicine, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Other systems of medicine, RZ201-999 |
| الوصف: | Inflammation is tightly associated with carcinogenesis at both the initiation and development of tumor. Many reports indicated that Cox-2 substantially contributes to inflammation and tumorigenesis. The novel nutraceutical KJS018A (BRM270 Function Enhanced Products) is the extract mixture from 8 herbal plants, which have been used to inhibit cancers and inflammation. The aim of the present study is to examine the inhibitory effects of KJS018A mixture to hepatocarcinogenesis and inflammation. The results showed that KJS018A significantly inhibited the proliferation of hepatic malignant cells and downregulated levels of IL-6 and Cox-2. Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. Furthermore, KJS018A suppressed metastatic traits of hepatic malignant cells via downregulating Twist, N-cadherin, and MMP-9 while restoring E-cadherin expression. KJS018A also restrained tumor growth and levels of IL-6 and Cox-2 in immunohistochemistry staining. Taken together, these data suggest potential application of KJS018A in prevention of hepatocarcinogenesis promoted by inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1741-427X 1741-4288 |
| Relation: | http://dx.doi.org/10.1155/2018/3909434; https://doaj.org/toc/1741-427X; https://doaj.org/toc/1741-4288; https://doaj.org/article/abc1eac392b849008d83c3ca25e7817b |
| DOI: | 10.1155/2018/3909434 |
| الاتاحة: | https://doi.org/10.1155/2018/3909434 https://doaj.org/article/abc1eac392b849008d83c3ca25e7817b |
| رقم الانضمام: | edsbas.EC91E53E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1741427X 17414288 |
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| DOI: | 10.1155/2018/3909434 |