Academic Journal
Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease
| العنوان: | Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease |
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| المؤلفون: | Esteve, Daniel, Molina-Navarro, María Micaela, Giraldo-Reboloso, Esther, Martínez-Varea, Noelia, Blanco-Gandia, Mari Carmen, Rodríguez-Arias, Marta, García-Verdugo, Jose Manuel, Viña, José, Lloret, Ana |
| المساهمون: | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural, European Commission, Generalitat Valenciana, Universitat de València, Instituto de Salud Carlos III, Agencia Estatal de Investigación, European Regional Development Fund |
| بيانات النشر: | Springer-Verlag |
| سنة النشر: | 2022 |
| المجموعة: | Universitat Politécnica de Valencia: RiuNet / Politechnical University of Valencia |
| مصطلحات موضوعية: | Subventricular zone, Beta-amyloid toxicity, Neurogenesis, Senescence, Olfaction, BIOLOGIA CELULAR |
| الوصف: | [EN] Neurogenesis in the adult brain takes place in two neurogenic niches: the ventricular-subventricular zone (V-SVZ) and the subgranular zone. After differentiation, neural precursor cells (neuroblasts) have to move to an adequate position, a process known as neuronal migration. Some studies show that in Alzheimer's disease, the adult neurogenesis is impaired. Our main aim was to investigate some proteins involved both in the physiopathology of Alzheimer's disease and in the neuronal migration process using the APP/PS1 Alzheimer's mouse model. Progenitor migrating cells are accumulated in the V-SVZ of the APP/PS1 mice. Furthermore, we find an increase of Cdh1 levels and a decrease of Cdk5/p35 and cyclin B1, indicating that these cells have an alteration of the cell cycle, which triggers a senescence state. We find less cells in the rostral migratory stream and less mature neurons in the olfactory bulbs from APP/PS1 mice, leading to an impaired odour discriminatory ability compared with WT mice. Alzheimer's disease mice present a deficit in cell migration from V-SVZ due to a senescent phenotype. Therefore, these results can contribute to a new approach of Alzheimer's based on senolytic compounds or pro-neurogenic factors. ; Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the following grants: Instituto de Salud Carlos III CB16/10/00435 (CIBER-FES), (PID2019-110906RB-I00/AEI/10.13039/501100011033) from the Spanish Ministry of Innovation and Science, PROMETEO/2019/097 from `Conselleria, de Sanitat de la Generalitat Valenciana' and EU Funded H2020-DIABFRAIL-LATAM (Ref: 825546), European Joint Programming Initiative `A Healthy Diet for a Healthy Life' (JPI HDHL) and of the ERA-NET Cofound ERA-HDHL (GA No 696295 of the EU Horizon 2020 Research and Innovation Programme). Part of the equipment employed in this work has been funded by Generalitat Valenciana and co-financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014-2020). Special Research ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0893-7648 |
| Relation: | Molecular Neurobiology; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110906RB-I00/ES/NUEVAS INTERVENCIONES TERAPEUTICAS MULTIDOMINIO PARA RETRASAR LA FRAGILIDAD Y LA DISCAPACIDAD. IDENTIFICACION DE MECANISMOS MOLECULARES CON RELEVANCIA TRASLACIONAL/; info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F097/; info:eu-repo/grantAgreement/EC/H2020/696295/EU; info:eu-repo/grantAgreement/ISCIII//CB16%2F10%2F00435//CIBER-FES/; info:eu-repo/grantAgreement/EC/H2020/825546/EU; info:eu-repo/grantAgreement/UV//UV-INV-AE-1546096/; https://doi.org/10.1007/s12035-021-02620-6; urn:issn:0893-7648; http://hdl.handle.net/10251/195605; PMC8857127 |
| DOI: | 10.1007/s12035-021-02620-6 |
| الاتاحة: | http://hdl.handle.net/10251/195605 https://doi.org/10.1007/s12035-021-02620-6 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EC42F2F0 |
| قاعدة البيانات: | BASE |
| تدمد: | 08937648 |
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| DOI: | 10.1007/s12035-021-02620-6 |