Academic Journal
A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs
| العنوان: | A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs |
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| المؤلفون: | Wendy A. Wambacq, Emmanuelle Apper, Cindy Le Bourgot, Florence Barbe, Yang Lyu, Michael Pelst, Bart J. G. Broeckx, Bert Devriendt, Eric Cox, Myriam Hesta |
| المصدر: | Frontiers in Veterinary Science, Vol 11 (2024) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | scFOS, prebiotic, postbiotic, immunosenescence, elderly dog, vaccine, Veterinary medicine, SF600-1100 |
| الوصف: | IntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fructo-oligosaccharides (scFOS) or postbiotics derived from yeasts may positively influence the immune response. The aim of the current study was to investigate whether dietary supplementation with a combination of scFOS with a new yeast postbiotic (Profeed ADVANCED® called scFOS+) could have a positive influence on the immune status of senior dogs subjected to an immune challenge (Lyme disease vaccination).MethodsTo this end, 22 healthy senior client-owned dogs were divided into two groups: one group received a placebo diet without scFOS+ and the other group the basal diet supplemented with 1.1% scFOS+. In order to assess immune function, complete blood count, serum acute phase proteins, immunoglobulins, cytokines, T-cell subsets and antibody secreting cells were analyzed. Furthermore, faecal score and pH were recorded.Results and discussionDogs fed the scFOS+ supplement had decreased total serum IgA concentrations (p < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with β-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (p < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1392985/full; https://doaj.org/toc/2297-1769; https://doaj.org/article/10e34e13330d4ad1b93670272568afdf |
| DOI: | 10.3389/fvets.2024.1392985 |
| الاتاحة: | https://doi.org/10.3389/fvets.2024.1392985 https://doaj.org/article/10e34e13330d4ad1b93670272568afdf |
| رقم الانضمام: | edsbas.EC1A28C5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fvets.2024.1392985 |
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