التفاصيل البيبلوغرافية
| العنوان: |
Low HDL and high triglycerides predict COVID-19 severity |
| المؤلفون: |
Masana, Luis, Correig Fraga, Eudald, Ibarretxe, Daiana, Anoro, Eva, Arroyo, Juan Antonio, Jericó, Carlos, Guerrero, Carolina, Miret, Marcel·la, Näf, Silvia, Pardo, Anna, Perea, Verónica, Pérez-Bernalte, Rosa, Plana, Núria, RamÃrez-Montesinos, Rafael, Royuela Juncadella, Meritxell, Soler, Cristina, Urquizu-Padilla, Maria, Zamora, Alberto, Pedro-Botet, Juan, Universitat Autònoma de Barcelona |
| سنة النشر: |
2021 |
| المجموعة: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: |
Dyslipidaemias, Risk factors |
| الوصف: |
Altres ajuts: The work was supported by unrestricted grants from the Institut de Investigació Sanità ria Pere Virgili (IISPV) and Xarxa de Unitat de Lipids i Ateriosclerosis (XULA) de Catalunya. ; Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Scientific reports; Vol. 11 (march 2021); https://ddd.uab.cat/record/255390; urn:10.1038/s41598-021-86747-5; urn:oai:ddd.uab.cat:255390; urn:pmcid:PMC8010012; urn:pmc-uid:8010012; urn:oai:pubmedcentral.nih.gov:8010012; urn:pmid:33785815 |
| الاتاحة: |
https://ddd.uab.cat/record/255390 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.EC0EA3AB |
| قاعدة البيانات: |
BASE |