Academic Journal
Validation of the Berlin Grading System for moyamoya angiopathy with the use of [15O]H2O PET
| العنوان: | Validation of the Berlin Grading System for moyamoya angiopathy with the use of [15O]H2O PET |
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| المؤلفون: | Mertens, R., Acker, G., Kersting, K., Lange, C., Furth, C., Beyaztas, D., Truckenmueller, P., Moedl, L., Spruenken, E. D., Czabanka, M., Vajkoczy, P. |
| سنة النشر: | 2022 |
| المجموعة: | FU Berlin: Refubium |
| مصطلحات موضوعية: | MMD, MMS, MMA, CVRC, PET, Berlin Grading, ddc:610 |
| الوصف: | The Berlin Grading System assesses clinical severity of moyamoya angiopathy (MMA) by combining MRI, DSA, and cerebrovascular reserve capacity (CVRC). Our aim was to validate this grading system using [O-15]H2O PET for CVRC. We retrospectively identified bilateral MMA patients who underwent [O-15]H2O PET examination and were treated surgically at our department. Each hemisphere was classified using the Suzuki and Berlin Grading System. Preoperative symptoms and perioperative ischemias were collected, and a logistic regression analysis was performed. A total of 100 hemispheres in 50 MMA patients (36 women, 14 men) were included. Using the Berlin Grading System, 2 (2.8%) of 71 symptomatic hemispheres were categorized as grade I, 14 (19.7%) as grade II, and 55 (77.5%) as grade III. The 29 asymptomatic hemispheres were characterized as grade I in 7 (24.1%) hemispheres, grade II in 12 (41.4%), and grade III in 10 (34.5%) hemispheres. Berlin grades were independent factors for identifying hemispheres as symptomatic and higher grades correlated with increasing proportion of symptomatic hemispheres (p < 0.01). The Suzuki grading did not correlate with preoperative symptoms (p = 0.26). Perioperative ischemic complications occurred in 8 of 88 operated hemispheres. Overall, complications did not occur in any of the grade I hemispheres, but in 9.1% (n = 2 of 22) and 9.8% (n = 6 of 61) of grade II and III hemispheres, respectively. In this study, we validated the Berlin Grading System with the use of [O-15]H2O PET for CVRC as it could stratify preoperative symptomatology. Furthermore, we highlighted its relevance for predicting perioperative ischemic complications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.17169/refubium-44899 |
| DOI: | 10.1007/s10143-022-01920-2 |
| الاتاحة: | https://refubium.fu-berlin.de/handle/fub188/45187 https://doi.org/10.17169/refubium-44899 https://doi.org/10.1007/s10143-022-01920-2 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.EC008A8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.17169/refubium-44899 |
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