Academic Journal
FEATURES OF DISORDERS ENERGY SUPPLYING OF THE MUSCLE OF LARGE INTESTINE AT CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION ; ОСОБЛИВОСТІ ПОРУШЕНЬ ЕНЕРГОЗАБЕЗПЕЧЕННЯ М’ЯЗОВОЇ ОБОЛОНКИ ТОВСТОЇ КИШКИ ЗА УМОВ ПОСТРЕЗЕКЦІЙНОЇ ПОРТАЛЬНОЇ ГІПЕРТЕНЗІЇ
| العنوان: | FEATURES OF DISORDERS ENERGY SUPPLYING OF THE MUSCLE OF LARGE INTESTINE AT CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION ; ОСОБЛИВОСТІ ПОРУШЕНЬ ЕНЕРГОЗАБЕЗПЕЧЕННЯ М’ЯЗОВОЇ ОБОЛОНКИ ТОВСТОЇ КИШКИ ЗА УМОВ ПОСТРЕЗЕКЦІЙНОЇ ПОРТАЛЬНОЇ ГІПЕРТЕНЗІЇ |
|---|---|
| المؤلفون: | Гнатюк, М. С., Процайло, О. М., Татарчук, Л. В., Монастирська, Н. Я., Коноваленко , С. О. |
| المصدر: | Medical and Clinical Chemistry; No. 2 (2022); 33-38 ; Медицинская и клиническая химия; № 2 (2022); 33-38 ; Медична та клінічна хімія; № 2 (2022); 33-38 ; 2414-9934 ; 2410-681X ; 10.11603/mcch.2410-681X.2022.i2 |
| بيانات النشر: | Ternopil National Medical University |
| سنة النشر: | 2022 |
| المجموعة: | Scientific Journals of Ternopil State Medical University / Наукові журнали Тернопільського державного медичного університету імені І.Я.Горбачевського |
| مصطلحات موضوعية: | postresection portal hypertension, large intestine, muscle, energy supply, пострезекційна портальна гіпертензія, товста кишка, м’язова оболонка, енергетичне забезпечення |
| الوصف: | Introduction. Postresection portal hypertension is complicated by plethora, lesions, deterioration of energy supply of the portal vein, which has not been studied in muscular membrane of the intestine. The aim of the study – to establish the features of disorders of energy supply of muscular membrane of the colon in conditions of postresection portal hypertension. Research Methods. The colon of 50 rats, which were divided into 3 groups, was biochemically and morphologically studied. Group 1 – 15 intact animals, 2 – 20 rats with postresection portal hypertension, 3 – 15 animals with a combination of postresection portal hypertension with multiorgan failure. Postresection portal hypertension was modeled by resection of left and right lateral lobes of the liver (58.1 % of its parenchyma). Rats were euthanized by bloodletting under anesthesia one month after the start of the experiment. The energy supply of the muscular membrane of the colon was determined by the content of ATP, ADP, AMP, ATP/ADP ratio. The thickness of muscular membrane of the colon, the relative volume of myocytes, stroma, damaged myocytes, stromal-myocyte ratios, diameter of myocytes, their nuclei, nuclear-cytoplasmic ratios in myocytes were measured on micropreparations. Correlation analysis was performed between biochemical and morphometric parameters. Quantitative values were processed statistically. Results and Discussion. Resection of 58.1 % of the liver parenchyma led to postresection portal hypertension, dilatation and plethora of the portal hepatic vein, mesenteric veins, venous bed of the small and large intestine, splenomegaly, ascites, rarely to the development of multiple organ failure. Dystrophy, necrobiosis of epitheliocytes, myocytes, endotheliocytes, stromal structures, infiltrative and sclerotic processes were found in the wall of the colon. In the muscular membrane, stromal-myocyte ratios increased by 19.4%, nuclear-cytoplasmic ratios in myocytes – by 6.7%, the relative volume of damaged myocytes – by 7.2 times, with development ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | https://ojs.tdmu.edu.ua/index.php/MCC/article/view/13203/12347; https://ojs.tdmu.edu.ua/index.php/MCC/article/view/13203 |
| DOI: | 10.11603/mcch.2410-681X.2022.i2.13203 |
| الاتاحة: | https://ojs.tdmu.edu.ua/index.php/MCC/article/view/13203 https://doi.org/10.11603/mcch.2410-681X.2022.i2.13203 |
| Rights: | Авторське право (c) 2022 Медична та клінічна хімія ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.EBED82D |
| قاعدة البيانات: | BASE |
| DOI: | 10.11603/mcch.2410-681X.2022.i2.13203 |
|---|