Academic Journal
The fate of spikes in self-limited epilepsy with centrotemporal spikes: Are clinical and baseline EEG features effective?
| العنوان: | The fate of spikes in self-limited epilepsy with centrotemporal spikes: Are clinical and baseline EEG features effective? |
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| المؤلفون: | Sarikaya Uzan, Gamze, Yiş, ULUÇ, Günay, ÇAĞATAY, Hiz Kurul, Semra, Özsoy, Özlem |
| سنة النشر: | 2023 |
| المجموعة: | Dokuz Eylül University: DSpace Repository |
| الوصف: | Objective: The aim of this study is to evaluate the effects of clinical and electroencephalographic features on spike reduction with a focus on the first EEG characteristics in self-limited epilepsy with centrotemporal spikes (SeLECTS).Methods: This retrospective study was conducted on SeLECTS patients of with at least five years follow-up and at least two EEG recordings in which spike wave indexes (SWI) were calculated. Results: 136 patients were enrolled. Median SWI in the first and last EEGs were 39% (7.6-89%) and 0 (0-112%). Gender, seizure onset age, psychiatric diseases, seizure characteristics (semiology, duration, and relationship to sleep), last EEG time, and spike lateralization in the first EEG did not have a statistically significant effect on the SWI change. Multinomial logistic regression analysis revealed that presence of phase reversal, interhemispheric generalization, and SWI percentage had a significant effect on spike reduction. The frequency of seizures was also significantly decreased in patients with a greater decrease in SWI. Both valproate and levetiracetam were statistically superior in suppressing SWI, with no significant difference between them.Conclusion: Interhemispheric generalization and phase reversal in the first EEG in SeLECTS had negative effects on the spike reduction. The most effective ASMs in reducing spikes were valproate and levetiracetam. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | 59eb34af-2074-4bc9-a7af-2dd4dcbb6850; https://avesis.deu.edu.tr/publication/details/59eb34af-2074-4bc9-a7af-2dd4dcbb6850/oai |
| DOI: | 10.1016/j.eplepsyres.2023.107165 |
| الاتاحة: | https://doi.org/10.1016/j.eplepsyres.2023.107165 https://avesis.deu.edu.tr/publication/details/59eb34af-2074-4bc9-a7af-2dd4dcbb6850/oai |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.EBD5C67B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.eplepsyres.2023.107165 |
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