Academic Journal
Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy
| العنوان: | Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy |
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| المؤلفون: | Azevedo, Ana Maria Milanez, Brites-Anselmi, Guilhermo, Pinheiro, Lucas Cezar, de Almeida Belo, Vanessa, Coeli-Lacchini, Fernanda Borchers, Molina, Carlos Augusto Fernandes, de Andrade, Murilo Ferreira, Tucci, Silvio, Hirsch, Emilio, Tanus-Santos, Jose Eduardo, Lacchini, Riccardo |
| المساهمون: | Azevedo, Ana Maria Milanez, Brites-Anselmi, Guilhermo, Pinheiro, Lucas Cezar, de Almeida Belo, Vanessa, Coeli-Lacchini, Fernanda Borcher, Molina, Carlos Augusto Fernande, de Andrade, Murilo Ferreira, Tucci, Silvio, Hirsch, Emilio, Tanus-Santos, Jose Eduardo, Lacchini, Riccardo* |
| سنة النشر: | 2017 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | ADMA, DDAH1, DDAH2, Erectile dysfunction, Nitric oxide, Sildenafil, Amidohydrolase, Arginine, Biomarker, Human, Male, Nitrite, Phosphodiesterase 5 Inhibitor, Polymorphism, Genetic, Sildenafil Citrate, Biochemistry, Physiology, Clinical Biochemistry, Cancer Research |
| الوصف: | Sildenafil is the most used treatment of erectile dysfunction, however a large part of patients do not respond to therapy. This drug enhances nitric oxide (NO) signaling, and therefore factors that alter NO production may impact this drug responsiveness. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of all NO synthases, and is metabolized by Dimethylarginine Dimethilaminohydrolase (DDAH) 1 and 2. Here we aimed to assess the relationship between plasma levels of ADMA and nitrite (marker of nitric oxide production) with Sildenafil responsiveness. We also studied genetic polymorphisms in DDAH1 and DDAH2 genes and their relation with biochemical and clinical data. Were included here 140 patients, divided in Clinical Erectile Dysfunction (CED) or Post-Prostatectomy Erectile Dysfunction (PPED) groups. Erectile function was evaluated before and after Sildenafil on-demand treatment using the International Index for Erectile Function Questionnaire. We have found that nitrite was associated with worse response to Sildenafil (r = - 0.25, P = 0.040). rs1554597 and rs18582 DDAH1 polymorphisms were associated with changes in ADMA levels in CED (B = - 0.23, P = 0.002; B = - 0.15, P = 0.017 for both variant genotypes, respectively). Finally, DDAH2 polymorphisms were associated with altered responsiveness to Sildenafil in PPED (B = +0.19, P = 0.027). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29074293; info:eu-repo/semantics/altIdentifier/wos/WOS:000415911000006; volume:71; issue:dicembre; firstpage:44; lastpage:51; numberofpages:8; journal:NITRIC OXIDE; http://hdl.handle.net/2318/1679054; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85032301208; http://www.elsevier.com/inca/publications/store/6/2/2/9/2/6/index.htt |
| DOI: | 10.1016/j.niox.2017.10.006 |
| الاتاحة: | http://hdl.handle.net/2318/1679054 https://doi.org/10.1016/j.niox.2017.10.006 http://www.elsevier.com/inca/publications/store/6/2/2/9/2/6/index.htt |
| رقم الانضمام: | edsbas.EBCD3C49 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.niox.2017.10.006 |
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