Academic Journal
Biothérapies pour les troubles de l’érection et la maladie de la Peyronie : ou en est-on ?
| العنوان: | Biothérapies pour les troubles de l’érection et la maladie de la Peyronie : ou en est-on ? |
|---|---|
| المؤلفون: | Akakpo, W., Schirmann, A., Ferretti, L., Ben-Naoum, K., Carnicelli, D., Graziana, J.-P., Hupertan, V., Madec, F.X., Marcelli, F., Methorst, C., Morel-Journel, N., Savareux, L., Terrier, J.E., Faix, A., Huyghe, E., Yiou, R. |
| المساهمون: | CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital d'Instruction des Armées Robert Picqué, Service de Santé des Armées, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service d'urologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique Beau Soleil Montpellier |
| المصدر: | ISSN: 1166-7087. |
| بيانات النشر: | CCSD Elsevier Masson |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Biotherapy, Biothérapie, Cell therapy, Cellules souches, Dysfonction érectile, Erectile dysfunction, Maladie de la Peyronie, Peyronie's disease, Plasma enrichi en plaquettes, Platelet-rich plasma, Stem cell, Thérapie cellulaire, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Introduction: Clinical trials of cell therapy for erectile dysfunction (ED) and Peyronie's disease (PD) were recently conducted after preclinical studies.Aims: The aims of this study are to give an update on biotherapy for ED and PD and to describe the regulatory framework for these therapies.Materials and methods: A literature review was performed through PubMed and Clinical.trials.gov addressing cell therapy for ED and PD and using following keywords "erectile dysfunction", "Peyronie's disease", "stem cell", and "platelet-rich plasma".Results: Preclinical studies in rodent models have shown the potential benefit of cell therapy for ED after radical prostatectomy or caused by metabolic diseases, and PD. The tissues used to obtain the therapeutic product were bone marrow, adipose tissue and blood (PRP, platelet-rich plasma). Mechanism of action was shown to be temporary and mainly paracrine. Four clinical trials were published concerning ED after radical prostatectomy and in diabetic patients and one for PD. Eleven clinical trials including three randomized trials are currently going on. Preclinical and preliminary clinical results suggested the possibility to improve spontaneous erectile function and response to pharmaceutical treatment in initially non-responder patients. This effect is mediated by an improvement of penile vascularization. A reduction of penile curvature without side effect was noted after injections into the plaque of PD patients. Most of these therapeutic strategies using autologous cells were considered as "Advanced Therapy Medicinal Products" with strict regulatory frameworks imposing heavy constraints, in particular in case of "substantial" modification of the cells. The regulatory framework remains unclear and more permissive for PRP and cell therapy processes with extemporaneous preparation/injection and no "substantial" modifications.Conclusions: First results on cell therapy for ED and PD are promising. The regulatory framework can significantly change ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32826194; PUBMED: 32826194 |
| DOI: | 10.1016/j.purol.2020.05.002 |
| الاتاحة: | https://hal.science/hal-03492954 https://hal.science/hal-03492954v1/document https://hal.science/hal-03492954v1/file/S1166708720301494.pdf https://doi.org/10.1016/j.purol.2020.05.002 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.EBC3BAD7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.purol.2020.05.002 |
|---|