Academic Journal
Light-Triggered Enantioselective Organocatalytic Mannich-Type Reaction
| العنوان: | Light-Triggered Enantioselective Organocatalytic Mannich-Type Reaction |
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| المؤلفون: | Hepburn H. B., Magagnano G., Melchiorre P. |
| المساهمون: | Hepburn H.B., Magagnano G., Melchiorre P. |
| سنة النشر: | 2017 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | enantioselective catalysi, Mannich-type reaction, organocatalysi, photochemistry, synthetic methods |
| الوصف: | Disclosed herein is a photochemical organocatalytic strategy for the direct enantioselective Mannich-type reaction of 2-alkylbenzophenones and cyclic imines. The chemistry exploits the light-triggered enolization of 2-alkylbenzophenones to generate transient hydroxy-o-quinodimethanes. These fleeting intermediates can be stereoselectively intercepted by imines upon activation with a chiral organic catalyst, derived from natural cinchona alkaloids. The developed method uses mild conditions, simple sources of illumination, and easily available substrates and catalysts, affording enantioenriched chiral amines that are difficult to synthesize by other approaches. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000393231000009; volume:49; issue:1; firstpage:76; lastpage:86; numberofpages:11; journal:SYNTHESIS; info:eu-repo/grantAgreement/EC/H2020/ERC-2015-CoG 681840; https://hdl.handle.net/11585/898158; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84990205066; https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588606 |
| DOI: | 10.1055/s-0036-1588606 |
| الاتاحة: | https://hdl.handle.net/11585/898158 https://doi.org/10.1055/s-0036-1588606 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588606 |
| رقم الانضمام: | edsbas.EB9E721F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/s-0036-1588606 |
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