Academic Journal
Improved Stability and Practicality for Synthesis of 4-Borono-2-[18F]fluoro-l-phenylalanine by Combination of [18O]O2 Single-Use and [18F]CH3COOF Labeling Agents
| العنوان: | Improved Stability and Practicality for Synthesis of 4-Borono-2-[18F]fluoro-l-phenylalanine by Combination of [18O]O2 Single-Use and [18F]CH3COOF Labeling Agents |
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| المؤلفون: | Naka, Sadahiro, Watanabe, Toshimitsu, Kanai, Yasukazu, Watabe, Tadashi, Tatsumi, Mitsuaki, Kato, Hiroki, Shimosegawa, Eku, Hatazawa, Jun |
| المصدر: | Nuclear Medicine and Molecular Imaging ; volume 56, issue 2, page 86-95 ; ISSN 1869-3474 1869-3482 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Purpose 4-Borono-2-[ 18 F]fluoro- l -phenylalanine ([ 18 F]FBPA) synthesized with [ 18 F]F 2 , produced using the 18 O(p, n) 18 F reaction, has been reported for increasing radioactivity. However, a dedicated system and complex procedure is required to reuse the costly [ 18 O]O 2 gas; also, the use of [ 18 F]F 2 as a labeling agent reduces the labeling rate and radiochemical purity. We developed a stable and practical method for [ 18 F]FBPA synthesis by combining [ 18 F]F 2 , produced using a [ 18 O]O 2 single-use system, and a [ 18 F]CH 3 COOF labeling agent. Methods The produced [ 18 F]F 2 was optimized, and then [ 18 F]FBPA was synthesized. For passivation of the target box, 0.5% F 2 was pre-irradiated in argon. Gaseous products were discarded; the target box was filled with [ 18 O]O 2 gas, and then irradiated (first irradiation). Then, the [ 18 O]O 2 gas was discarded, 0.05–0.08% F 2 in argon was fed into the target box, and it was again irradiated (second irradiation). The [ 18 F]F 2 obtained after this was passed through a CH 3 COONa column, converting it into the [ 18 F]CH 3 COOF labeling agent, which was then used for [ 18 F]FBPA synthesis. Results The mean amount of as-obtained [ 18 F]F 2 was 55.0 ± 3.3 GBq and that of as-obtained [ 18 F]CH 3 COOF was 21.6 ± 1.4 GBq after the bombardment. The radioactivity and the radiochemical yield based on [ 18 F]F 2 of [ 18 F]FBPA were 4.72 ± 0.34 GBq and 12.2 ± 0.1%, respectively. The radiochemical purity and molar activity were 99.3 ± 0.1% and 231 ± 22 GBq/mmol, respectively. Conclusion We developed a method for [ 18 F]FBPA production, which is more stable and practical compared with the method using [ 18 O]O 2 gas-recycling and [ 18 F]F 2 labeling agent. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s13139-021-00719-1 |
| DOI: | 10.1007/s13139-021-00719-1.pdf |
| DOI: | 10.1007/s13139-021-00719-1/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s13139-021-00719-1 https://link.springer.com/content/pdf/10.1007/s13139-021-00719-1.pdf https://link.springer.com/article/10.1007/s13139-021-00719-1/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.EB7D1D40 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13139-021-00719-1 |
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