Academic Journal
Neural alterations underlying executive dysfunction in Parkinson’s disease: A systematic review and coordinate-based meta-analysis of functional neuroimaging studies
| العنوان: | Neural alterations underlying executive dysfunction in Parkinson’s disease: A systematic review and coordinate-based meta-analysis of functional neuroimaging studies |
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| المؤلفون: | Arrigoni, E, Antoniotti, P, Bellocchio, V, Veronelli, L, Corbo, M, Pisoni, A |
| المساهمون: | Arrigoni, E, Antoniotti, P, Bellocchio, V, Veronelli, L, Corbo, M, Pisoni, A |
| بيانات النشر: | Elsevier Ireland Ltd. IE |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | Coordinate-based meta-analysi, Executive function, Functional neuroimaging, Parkinson's disease |
| الوصف: | Parkinson's Disease's (PD) neuropsychological profile is often characterized by altered performance in executive functions (EF) tasks, with a remarkable impact on patients’ quality of life. To date, the available neuroimaging literature lacks conclusive evidence about neural patterns underlying EF deficits in PD. Here, we aimed to synthesize the results of PET/fMRI studies examining the differences in brain activation between PD patients and controls during EF tasks, focusing on the three main EF sub-components: cognitive flexibility, working memory, and response inhibition. We conducted a coordinate-based meta-analysis to assess the converging alterations in brain activity in PD patients compared to controls. We assessed the association between aberrant patterns of activity and the EF sub-domains. We found a significant association between hypoactivation patterns in PD converging at the level of the right inferior frontal gyrus in response inhibition tasks, whereas hypoactivation in the left inferior frontal gyrus was found in association with the cognitive flexibility domain. Our results confirm the existence of neural alterations in PD patients in relation to specific EF sub-domains. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38281709; volume:95; issue:March 2024; journal:AGEING RESEARCH REVIEWS; https://hdl.handle.net/10281/462841; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85185885504 |
| DOI: | 10.1016/j.arr.2024.102207 |
| الاتاحة: | https://hdl.handle.net/10281/462841 https://doi.org/10.1016/j.arr.2024.102207 |
| رقم الانضمام: | edsbas.EB7A49E8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.arr.2024.102207 |
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