Academic Journal
Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG)
| العنوان: | Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG) |
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| المؤلفون: | van Beek, D.-J. (Dirk-Jan), Nell, S. (Sjoerd), Pieterman, C.R.C. (Carolina), Herder, W.W. (Wouter) de, Ven, A.C. (Annenienke) van de, Dekkers, O.M. (Olaf), Horst-Schrivers, A.N.A. (Anouk) van der, Drent, M.L. (Madeleine), Bisschop, P.H. (Peter), Havekes, B. (Bas), Borel Rinkes, I.H.M. (Inne), Vriens, M.R. (Menno), Valk, G.D. (Gerlof) |
| المصدر: | Journal of Surgical Oncology |
| سنة النشر: | 2019 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | multiple endocrine neoplasia type 1, neuroendocrine tumor, oncology, Zollinger-Ellison syndrome |
| الوصف: | Background and objectives: Gastrinomas are the most prevalent functioning neuroendocrine tumors (NET) in multiple endocrine neoplasia type 1 (MEN1). Guidelines suggest medical therapy in most patients, but surgery may be considered in a subgroup. Currently, factors to guide management are necessary. This population-based cohort study assessed prognostic factors of survival in patients with MEN1-related gastrinomas. Methods: Patients with MEN1 having gastrinomas were identified in the Dutch MEN1 database from 1990 to 2014 based on fasting serum gastrin (FSG) levels and/or pathology. Predictors of overall survival were assessed using Cox regression. Results: Sixty-three patients with gastrinoma (16% of the MEN1 population) were identified. Five- and 10-year overall survival rates were 83% and 65%, respectively. Prognostic factors associated with overall survival were initial FSG levels ≥20x upper limit of normal (ULN) (hazard ratio [HR], 6.2 [95% confidence interval, 1.7-23.0]), pancreatic NET ≥2 cm (HR 4.5; [1.5-13.1]), synchronous liver metastases (HR 8.9; [2.1-36.7]), gastroduodenoscopy suspicious for gastric NETs (HR 12.7; [1.4-115.6]), and multiple concurrent NETs (HR 5.9; [1.2-27.7]). Conclusion: Life expectancy of patients with MEN1 gastrinoma is reduced. FSG levels and pancreatic NETs ≥2 cm are prognostic factors. FSG levels might guide surveillance intensity, step-up to additional diagnostics, or provide arguments in selecting patients who might benefit from surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://repub.eur.nl/pub/118670; urn:hdl:1765/118670 |
| DOI: | 10.1002/jso.25667 |
| الاتاحة: | http://repub.eur.nl/pub/118670 https://doi.org/10.1002/jso.25667 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EB73402F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jso.25667 |
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