Academic Journal
The added value of SLN mapping with indocyanine green in low- and intermediate-risk endometrial cancer management:a systematic review and meta-analysis
| العنوان: | The added value of SLN mapping with indocyanine green in low- and intermediate-risk endometrial cancer management:a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Burg, Lara C, Verheijen, Shenna, Bekkers, Ruud L M, IntHout, Joanna, Holloway, Robert W, Taskin, Salih, Ferguson, Sarah E, Xue, Yu, Ditto, Antonino, Baiocchi, Glauco, Papadia, Andrea, Bogani, Giorgio, Buda, Alessandro, Kruitwagen, Roy F P M, Zusterzeel, Petra L M |
| المصدر: | Burg , L C , Verheijen , S , Bekkers , R L M , IntHout , J , Holloway , R W , Taskin , S , Ferguson , S E , Xue , Y , Ditto , A , Baiocchi , G , Papadia , A , Bogani , G , Buda , A , Kruitwagen , R F P M & Zusterzeel , P L M 2022 , ' The added value of SLN mapping with indocyanine green in low- and intermediate-risk endometrial cancer management : a systematic review and meta-analysis ' , Journal of Gynecologic .... |
| سنة النشر: | 2022 |
| المجموعة: | Maastricht University Research Publications |
| الوصف: | OBJECTIVE: The aim of this study was to assess the SLN detection rate in presumed early stage, low- and intermediate-risk endometrial cancers, the incidence of SLN metastases, and the negative predictive value of SLN mapping performed with indocyanine green (ICG). METHODS: A systematic review with meta-analyses was conducted. Study inclusion criteria were A) low- and intermediate-risk endometrial cancer, B) the use of ICG per cervical injection; C) a minimum of twenty included patients per study. To assess the negative predictive value of SLN mapping, D) a subsequent lymphadenectomy was an additional inclusion criterion. RESULTS: Fourteen studies were selected, involving 2,117 patients. The overall and bilateral SLN detection rates were 95.6% (95% confidence interval [CI]=92.4%-97.9%) and 76.5% (95% CI=68.1%-84.0%), respectively. The incidence of SLN metastases was 9.6% (95% CI=5.1%-15.2%) in patients with grade 1-2 endometrial cancer and 11.8% (95% CI=8.1%-16.1%) in patients with grade 1-3 endometrial cancer. The negative predictive value of SLN mapping was 100% (95% CI=98.8%-100%) in studies that included grade 1-2 endometrial cancer and 99.2% (95% CI=97.9%-99.9%) in studies that also included grade 3. CONCLUSION: SLN mapping with ICG is feasible with a high detection rate and negative predictive value in low- and intermediate-risk endometrial cancers. Given the incidence of SLN metastases is approximately 10% in those patients, SLN mapping may lead to stage shifting with potential therapeutic consequences. Given the high negative predictive value with SLN mapping, routine lymphadenectomy should be omitted in low- and intermediate-risk endometrial cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://cris.maastrichtuniversity.nl/en/publications/e0532b7a-e043-4c3b-b8f2-b8b867aed5ad |
| DOI: | 10.3802/jgo.2022.33.e66 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/e0532b7a-e043-4c3b-b8f2-b8b867aed5ad https://doi.org/10.3802/jgo.2022.33.e66 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EB42148E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3802/jgo.2022.33.e66 |
|---|