Academic Journal

Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes

التفاصيل البيبلوغرافية
العنوان: Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes
المؤلفون: Beattie, WS, Lalu, M, Bocock, M, Feng, S, Wijeysundera, DN, Nagele, P, Fleisher, LA, Kurz, A, Biccard, B, Leslie, K, Howell, S, Landoni, G, Grocott, H, Lamy, A, Richards, T, Myles, P, Cooper, DJ, Gan, TJ, Peyton, P, Sessler, D, Tramèr, M, Cyna, A, De Oliveira, GS, Wu, C, Jensen, M, Kehlet, H, Botti, M, Boney, O, Haller, G, Grocott, M, Cook, T, Fleisher, L, Neuman, M, Story, D, Gruen, R, Bampoe, S, Evered, L, Scott, D, Silbert, B, van Dijk, D, Kalkman, C, Chan, M, Eckenhoff, R, Rasmussen, L, Eriksson, L, Beattie, S, Wijeysundera, D, Bartlett, RJ, McMonnies, R, Gerstl, J, Jay, M, Kishlyansky, D, Machina, M, Bobcock, M, Pearse, R, Mythen, M, Canet, J, Moller, A, Gin, T, Schultz, M, Pelosi, P, Gabreu, M, Futier, E, Creagh-Brown, B, Abbott, T, Klein, A, Corcoran, T, Dieleman, S, Diouf, E, McIlroy, D, Bellomo, R, Shaw, A, Prowle, J, Karkouti, K, Billings, J, Mazer, D, Jayarajah, M, Murphy, M, Bartoszko, J, Sneyd, R, Morris, S, George, R, Moonesinghe, R, Shulman, M, Lane-Fall, M, Nilsson, U, Stevenson, N, Cooper, J, van Klei, W, Cabrini, L, Miller, T, Pace, N, Jackson, S, Buggy, D, Short, T, Riedel, B, Gottumukkala, V, Alkhaffaf, B
المصدر: British Journal of Anaesthesia , 126 (1) pp. 56-66. (2021)
بيانات النشر: ELSEVIER SCI LTD
سنة النشر: 2021
المجموعة: University College London: UCL Discovery
مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Anesthesiology, cardiovascular events, clinical trials, MACE, myocardial infarction, outcome measures, perioperative medicine, standardised endpoint, NONCARDIAC SURGERY, MYOCARDIAL INJURY, 30-DAY MORTALITY, TROPONIN LEVELS, CARDIAC RISK, ASSOCIATION, GUIDELINES, MANAGEMENT, SOCIETY
الوصف: Background: Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of perioperative cardiovascular adverse events are heterogeneous. As part of the international Standardized Endpoints in Perioperative Medicine initiative, this study aimed to find consensus amongst clinical trialists on a set of standardised and valid cardiovascular outcomes for use in future perioperative clinical trials. Methods: We identified currently used perioperative cardiovascular outcomes by a systematic review of the anaesthesia and perioperative medicine literature (PubMed/Ovid, Embase, and Cochrane Library). We performed a three-stage Delphi consensus-gaining process that involved 55 clinician researchers worldwide. Cardiovascular outcomes were first shortlisted and the most suitable definitions determined. These cardiovascular outcomes were then assessed for validity, reliability, feasibility, and clarity. Results: We identified 18 cardiovascular outcomes. Participation in the three Delphi rounds was 100% (n=19), 71% (n=55), and 89% (n=17), respectively. A final list of nine cardiovascular outcomes was elicited from the consensus: myocardial infarction, myocardial injury, cardiovascular death, non-fatal cardiac arrest, coronary revascularisation, major adverse cardiac events, pulmonary embolism, deep vein thrombosis, and atrial fibrillation. These nine cardiovascular outcomes were rated by the majority of experts as valid, reliable, feasible, and clearly defined. Conclusions: These nine consensus cardiovascular outcomes can be confidently used as endpoints in clinical trials designed to evaluate perioperative interventions with the goal of improving perioperative outcomes.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: https://discovery.ucl.ac.uk/id/eprint/10145987/1/1-s2.0-S0007091220307807-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10145987/
الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10145987/1/1-s2.0-S0007091220307807-main.pdf
https://discovery.ucl.ac.uk/id/eprint/10145987/
Rights: open
رقم الانضمام: edsbas.EB316D8
قاعدة البيانات: BASE