Academic Journal
Vasa, a regulator of localized mRNA translation on the spindle
| العنوان: | Vasa, a regulator of localized mRNA translation on the spindle |
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| المؤلفون: | Sundaram Buitrago, Paola Alejandra, Rao, Kavya, Yajima, Mamiko |
| المساهمون: | National Institutes of Health, National Science Foundation |
| المصدر: | BioEssays ; volume 45, issue 4 ; ISSN 0265-9247 1521-1878 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Localized mRNA translation is a biological process that allows mRNA to be translated on‐site, which is proposed to provide fine control in protein regulation, both spatially and temporally within a cell. We recently reported that Vasa, an RNA‐helicase, is a promising factor that appears to regulate this process on the spindle during the embryonic development of the sea urchin, yet the detailed roles and functional mechanisms of Vasa in this process are still largely unknown. In this review article, to elucidate these remaining questions, we first summarize the prior knowledge and our recent findings in the area of Vasa research and further discuss how Vasa may function in localized mRNA translation, contributing to efficient protein regulation during rapid embryogenesis and cancer cell regulation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/bies.202300004 |
| الاتاحة: | http://dx.doi.org/10.1002/bies.202300004 https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.202300004 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/bies.202300004 https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/bies.202300004 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#am ; http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.EADB301D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/bies.202300004 |
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