Academic Journal
Melanin-concentrating hormone and its receptor are expressed and functional in human skin
| العنوان: | Melanin-concentrating hormone and its receptor are expressed and functional in human skin |
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| المؤلفون: | Thody, Anthony J., Hoogduijn, Martin J., Ancans, Janis, Estdale, Siân E., Suzuki, I. |
| سنة النشر: | 2009 |
| المجموعة: | Bradford Scholars@University of Bradford |
| مصطلحات موضوعية: | Melanocyte, MCH, MCHR1, ¿-MSH, Skin, Pigmentation |
| الوصف: | No ; In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the ¿-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of ¿-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Thody, A.J., Hoogduijn, M.D., Ancans, J., Estdale, S. et al (2002). Melanin-concentrating hormone and its receptor are expressed and functional in human skin. Biochemical and Biophysical Research Communications. Vol. 296, No.3, pp.698-701.; http://hdl.handle.net/10454/2739; https://doi.org/10.1016/S0006-291X(02)00932-4 |
| DOI: | 10.1016/S0006-291X(02)00932-4 |
| الاتاحة: | http://hdl.handle.net/10454/2739 https://doi.org/10.1016/S0006-291X(02)00932-4 |
| رقم الانضمام: | edsbas.EAD0BA14 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0006-291X(02)00932-4 |
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