Academic Journal
Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia
| العنوان: | Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia |
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| المؤلفون: | Adriaansen, B.P.H., Kamphuis, J.S., Schröder, A.M., Olthaar, A.J., Bock, C., Brandt, A., Stikkelbroeck, N., Lentjes, E., Span, P.N., Sweep, F.C.G.J., Claahsen-van der Grinten, H.L., Herwaarden, A.E. van |
| المصدر: | Clinical Endocrinology, 97, 1, pp. 36-42 |
| سنة النشر: | 2022 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences, Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences, Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences, Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences |
| الوصف: | Contains fulltext : 251424.pdf (Publisher’s version ) (Open Access) ; OBJECTIVE: Treatment of congenital adrenal hyperplasia (CAH) patients with glucocorticoids is often challenging since there is a delicate balance between over- and undertreatment. Treatment can be monitored noninvasively by measuring salivary androstenedione (A4) and 17-hydroxyprogesterone (17-OHP). Optimal treatment monitoring requires the establishment of reference values in saliva. DESIGN: A descriptive study. PATIENTS: For this study saliva of 255 healthy paediatric and adult volunteers with an age range of 4-75 years old was used. MEASUREMENTS: We developed a sensitive liquid chromatography-tandem mass spectrometry method, assessed salivary A4 and 17-OHP stability, and measured A4 and 17-OHP concentrations in saliva collected in the morning, afternoon, and evening. RESULTS: We quantified A4 and 17-OHP concentrations in the morning, afternoon, and evening and demonstrated that there is a significant rhythm with the highest levels in the morning and decreasing levels over the day. A4 and 17-OHP concentrations display an age-dependent pattern. These steroids remain stable in saliva at ambient temperature for up to 5 days. CONCLUSIONS: Good stability of the steroids in saliva enables saliva collection by the patient at home. Since salivary A4 and 17-OHP display a diurnal rhythm and age-dependent pattern, we established reference values for both children and adults at three time points during the day. These reference values support treatment monitoring of children and adults with CAH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://repository.ubn.ru.nl//bitstream/handle/2066/251424/251424.pdf; https://repository.ubn.ru.nl/handle/2066/251424 |
| DOI: | 10.1111/cen.14690 |
| الاتاحة: | https://repository.ubn.ru.nl//bitstream/handle/2066/251424/251424.pdf https://repository.ubn.ru.nl/handle/2066/251424 https://doi.org/10.1111/cen.14690 |
| رقم الانضمام: | edsbas.EACDE590 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cen.14690 |
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