Academic Journal
Biomarkers in acute kidney injury – pathophysiological basis and clinical performance
| العنوان: | Biomarkers in acute kidney injury – pathophysiological basis and clinical performance |
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| المؤلفون: | Schrezenmeier, E. V., Barasch, J., Budde, K., Westhoff, T., Schmidt‐Ott, K. M. |
| المساهمون: | Deutsche Forschungsgemeinschaft, Charité Universitätsmedizin Berlin |
| المصدر: | Acta Physiologica ; volume 219, issue 3, page 556-574 ; ISSN 1748-1708 1748-1716 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Various biomarkers of acute kidney injury ( AKI ) have been discovered and characterized in the recent past. These molecules can be detected in urine or blood and signify structural damage to the kidney. Clinically, they are proposed as adjunct diagnostics to serum creatinine and urinary output to improve the early detection, differential diagnosis and prognostic assessment of AKI . The most obvious requirements for a biomarker include its reflection of the underlying pathophysiology of the disease. Hence, a biomarker of AKI should derive from the injured kidney and reflect a molecular process intimately connected with tissue injury. Here, we provide an overview of the basic pathophysiology, the cellular sources and the clinical performance of the most important currently proposed biomarkers of AKI : neutrophil gelatinase‐associated lipocalin ( NGAL ), kidney injury molecule‐1 ( KIM ‐1), liver‐type fatty acid‐binding protein (L‐ FABP ), interleukin‐18 ( IL ‐18), insulin‐like growth factor‐binding protein 7 ( IGFBP 7), tissue inhibitor of metalloproteinase 2 ( TIMP ‐2) and calprotectin (S100A8/9). We also acknowledge each biomarker's advantages and disadvantages as well as important knowledge gaps and perspectives for future studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/apha.12764 |
| الاتاحة: | http://dx.doi.org/10.1111/apha.12764 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapha.12764 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apha.12764 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.EAB436C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/apha.12764 |
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